ID A0A087QU12_APTFO Unreviewed; 417 AA.
AC A0A087QU12;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1 {ECO:0000256|ARBA:ARBA00039805};
DE EC=2.7.8.27 {ECO:0000256|ARBA:ARBA00038996};
DE AltName: Full=Sphingomyelin synthase 1 {ECO:0000256|ARBA:ARBA00042067};
DE Flags: Fragment;
GN ORFNames=AS27_08820 {ECO:0000313|EMBL:KFM04716.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM04716.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM04716.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM04716.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; KL225904; KFM04716.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087QU12; -.
DR STRING; 9233.A0A087QU12; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01610; PAP2_like; 1.
DR CDD; cd09514; SAM_SGMS1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF28; PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF18016; SAM_3; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KFM04716.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 139..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..74
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM04716.1"
FT NON_TER 417
FT /evidence="ECO:0000313|EMBL:KFM04716.1"
SQ SEQUENCE 417 AA; 49081 MW; 1F2B7DC44E547B29 CRC64;
LPGKMKEVVL WSPEEVMNWL TENAVPEYCE PLKSFTGQDL INLTEEDFKK TPLSRVSSDS
GQRLLHMIET LKMAHHIEAH KNGHINGHIR VSVSNTTREN GFSSKMKLNG MPNGYKKEMI
KIPMPEPERS QYPMEWGKTF LAFIYALFCF IFTTVTISVV HERVPPKEVQ PPLPDAFFDR
FDRVQWAFSI CEINGMILVG LWFVQWLLLK YKSIISRRFF CIVGTLYLYR CITMYVTTLP
VPGMHFKCSP KLFGDWESHL RRIMKLIAGG GLSITGSHNM CGDYLYSGHT VILTLTYLFI
KEYSPRRLWW YHWLCWALSM VGMFCILLAH DHYTVDVVVA YYITTRLFWW YHTMANQQVL
KEASQTNLLA RVWWYKPFQY FEKNVQGIVP RSYHWPFPWP VLHRGRQVKY SRLVNDT
//
