ID A0A087QUZ8_APTFO Unreviewed; 777 AA.
AC A0A087QUZ8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Thyroid peroxidase {ECO:0000313|EMBL:KFM05052.1};
DE Flags: Fragment;
GN ORFNames=AS27_15706 {ECO:0000313|EMBL:KFM05052.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM05052.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM05052.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM05052.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; KL225942; KFM05052.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087QUZ8; -.
DR STRING; 9233.A0A087QUZ8; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0004447; F:iodide peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR GO; GO:0006590; P:thyroid hormone generation; IEA:InterPro.
DR CDD; cd00033; CCP; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd09825; thyroid_peroxidase; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR029589; TPO.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF60; THYROID PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00084; Sushi; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SMART; SM00032; CCP; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxidase {ECO:0000313|EMBL:KFM05052.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT DOMAIN 670..726
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT BINDING 424
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM05052.1"
FT NON_TER 777
FT /evidence="ECO:0000313|EMBL:KFM05052.1"
SQ SEQUENCE 777 AA; 86916 MW; 13C7CF3D21FB84AA CRC64;
RNIQGRGIAT PTLLLAFSKF PEQESQDISQ AAERMEMSIQ VLKQKVCQKH KRSLHPTDLL
SADLLTMIAN ISGCLPYMSP PKCPNNCLAN KYRLITGACN NREHPLWGAS NTALARWLPP
AYDDGLSQPR GWDPSVRYNG VQLPLVHEVT KKIIHASNEA VTEDNLYSDI IMVWGQYIDH
DIAFTPQSTS RTTFLTGMEC QMTCEKQNPC FPIKVTTNDT LTAGMNCLPF YRSSPACGTG
NHGIFSGNLS ALNPRQQING LTSFLDASTV YGSTPVVENK LRNLTSKEGL LRVNVKYYDN
HREYLPFTDQ IPSPCAQDSN ASEGERIECF MAGDSRSSEV TSLAAMHTLA LKNINGHWTA
ETVYQEARKI VGALHQIITL RDYIPKIIGP DAFNLYIGLY TGYDPTMNPT VSNVFSTAAF
RFGHATIQPI VRRLNAQYLD DPELPNLHLH EVFFSPWRLI KGGGLDPLLR GLLAHSAKLQ
MQDQLLNEEL TEKLFVLSNN GSLDLASLNL QRGRDHGLPG YNDWREFCGL PKLETQTDLN
TVITNHNVTE KILESYHNPN NIDVWLGGLV EDFLPGARTG PLFACIIGKQ MKALRDGDRF
WWENDNVFTE AQKHELKKHS LSRVICDNTG ISEVPVDAFK LGKFPQDFKH CDDIPGMNLE
AWQEFYQEEE ICGTPKSVEN GDFVYCSKFG KSTVTYSCQY GFQLQGEEQL TCTSKGWNFE
APVCIDINEC ENEINPPCSP SAKCINTKGS YKCLYTDPYK LAEDGRTCIG NACEPTV
//
