ID A0A087QX67_APTFO Unreviewed; 1046 AA.
AC A0A087QX67;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Solute carrier family 12 member 4 {ECO:0000313|EMBL:KFM05821.1};
DE Flags: Fragment;
GN ORFNames=AS27_09148 {ECO:0000313|EMBL:KFM05821.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM05821.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM05821.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM05821.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; KL225962; KFM05821.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087QX67; -.
DR STRING; 9233.A0A087QX67; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 85..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 85..260
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 366..656
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 670..787
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 800..1046
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM05821.1"
FT NON_TER 1046
FT /evidence="ECO:0000313|EMBL:KFM05821.1"
SQ SEQUENCE 1046 AA; 116271 MW; 98FFC4D16B565D43 CRC64;
HGNHKENSPF LNSSEAGKGG DYYDRNLALF EEELDIRPKV SSLLGKLVNY TNLTQGVKEH
EEAESTDGSK KKVSKSPSMG TLMGVYLPCM QNIFGVILFL RLTWMVGMAG VLQSFLIVLL
CCCCTMLTTI SMSAIATNGV VPAGGSYFMI SRSLGPEFGG AVGLCFYLGT TFAGAMYILG
AIEILLTYIV PQAAIFHSSG AHDASSAMLN NMRVYGTVFL ILMAVVVFVG VKYVNKFASL
FLACVVISIL SIYAGAIKSI FDPPEFPICM LGNRTLSRDQ FDVCAKTIVK DNITVPSKLW
QLFCHSTNLT TENCDEYFLM NNVSEIAGIP GAASGILKDN LWSNYLEKGE ILEKAHHPSV
DVAGQKNNLH LYVLSDIATS FMVLVGIFFP SVTGIMAGSN RSGDLKDAQK SIPVGTILAI
VTTSLVYFSC VLLFGACIEG VVLRDKYGEA VNKNLVVGTL SWPSPWVIVI GSFFSTCGAG
LQSLTGAPVA AQAIAKDNII PFLWVFGHGK ANGEPTWALL LTALIAELGI LIASLDMVAP
ILSMFFLMCY LFVNLACAVQ TLLRTPNWRP RFKYYHWALS FLGMSICLAL MFISSWYYAL
VAMLIAGMIY KYIEYQGAEK EWGDGIRGLS LSAARYALLR LEEGPPHTKN WRPQLLVLLK
LDEDLHVKYP RLLTFASQLK AGKGLTIIGS VIQGNFLETY GEAQAAEQTI KNMMDIEKVK
GFCQVVVANK VREGIAHLIQ SCGLGGMKHN TVVLGWPYGW RQSEDPRSWK TFIGTVRCTT
AAHLALLVPK NVSFYPSNHE RYNEGNIDVW WIVHDGGMLM LLPFLLKQHK VWRKCKMRIF
TVAQMDDNSI QMKKDLATFL YQLRIEAEVE VVEMHNSDIS AYTYERTLMM EQRSQMLRQM
RLTKTERERE AQLVKDRHSI ARLESLYSDE EDEGDPVPEN IQMTWTKEKC DAEKRNRGSA
VGSFRDLISI KPNQSNVRRM HTAVKLNEVI VNRSHDARLV LLNMPGPPKN TDGDENYMEF
LEVLTEGLER VLLVRGGGRE VITIYS
//
