ID A0A087QYU4_APTFO Unreviewed; 418 AA.
AC A0A087QYU4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=AP-3 complex subunit mu-1 {ECO:0000256|ARBA:ARBA00041150};
DE AltName: Full=AP-3 adaptor complex mu3A subunit {ECO:0000256|ARBA:ARBA00041639};
DE AltName: Full=Adaptor-related protein complex 3 subunit mu-1 {ECO:0000256|ARBA:ARBA00043091};
DE AltName: Full=Mu-adaptin 3A {ECO:0000256|ARBA:ARBA00041291};
DE AltName: Full=Mu3A-adaptin {ECO:0000256|ARBA:ARBA00042377};
GN ORFNames=AS27_02518 {ECO:0000313|EMBL:KFM06398.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM06398.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM06398.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM06398.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC not clathrin-associated. The complex is associated with the Golgi
CC region as well as more peripheral structures. It facilitates the
CC budding of vesicles from the Golgi membrane and may be directly
CC involved in trafficking to lysosomes. In concert with the BLOC-1
CC complex, AP-3 is required to target cargos into vesicles assembled at
CC cell bodies for delivery into neurites and nerve terminals.
CC {ECO:0000256|ARBA:ARBA00025605}.
CC -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC {ECO:0000256|ARBA:ARBA00005324, ECO:0000256|PIRNR:PIRNR005992}.
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DR EMBL; KL226002; KFM06398.1; -; Genomic_DNA.
DR RefSeq; XP_009275923.1; XM_009277648.1.
DR AlphaFoldDB; A0A087QYU4; -.
DR STRING; 9233.A0A087QYU4; -.
DR GeneID; 103897591; -.
DR KEGG; afor:103897591; -.
DR CTD; 26985; -.
DR OrthoDB; 831588at2759; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14837; AP3_Mu_N; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR001392; Clathrin_mu.
DR InterPro; IPR018240; Clathrin_mu_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR028565; MHD.
DR PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR PANTHER; PTHR10529:SF342; AP-3 COMPLEX SUBUNIT MU-1; 1.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF005992; Clathrin_mu; 1.
DR PRINTS; PR00314; CLATHRINADPT.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00990; CLAT_ADAPTOR_M_1; 1.
DR PROSITE; PS00991; CLAT_ADAPTOR_M_2; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005992};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005992}.
FT DOMAIN 176..417
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
SQ SEQUENCE 418 AA; 47030 MW; 807C24ABACC4C51C CRC64;
MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAI DVENVPPVIS TPHHYLISIY
RDKIFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSET AIKDNVVIVY ELLEEMLDNG
FPLATESNIL KELIKPPTIL RSVVNSITGS SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY
FDVVEEIDAI IDKSGSTVFA EIQGVIDSCI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK
RWESERVLSF IPPDGNFRLI SYRVSSQNLV AIPVYVKHMI SFKENSSSGR FDVTIGPKQN
MGKTVEGVVM TVHMPKAVLN MNLTATQGSY TFDPVTKVLT WDVGKITPQK LPNLKGIVNL
QSGAPKPEEN PSLNIQFKIQ QLAISGLKVN RLDMYGEKYK PFKGVKYITK AGKFQVRT
//
