ID A0A087R026_APTFO Unreviewed; 1662 AA.
AC A0A087R026;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Clathrin heavy chain 1 {ECO:0000313|EMBL:KFM06830.1};
DE Flags: Fragment;
GN ORFNames=AS27_13509 {ECO:0000313|EMBL:KFM06830.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM06830.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM06830.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM06830.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00004277}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004277}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004277}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535}.
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DR EMBL; KL226004; KFM06830.1; -; Genomic_DNA.
DR STRING; 9233.A0A087R026; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF7; CLATHRIN HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 5.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 318..341
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM06830.1"
FT NON_TER 1662
FT /evidence="ECO:0000313|EMBL:KFM06830.1"
SQ SEQUENCE 1662 AA; 190061 MW; EC8F064D19171A6A CRC64;
QLQNLGINPA NIGFSTLTME SDKFICIREK VGEQAQVVII DMNDPSNPIR RPISADSAIM
NPASKVIALK AGKTLQIFNI EMKSKMKAHT MTDDVTFWKW ISLNTVALVT DNAVYHWSME
GESQPVKMFD RHSSLAGCQI INYRTDAKQK WLLLTGISAQ QNRVVGAMQL YSVDRKVSQP
IEGHAASFAQ FKMEGNAEES TLFCFAVRGQ AGGKLHIIEV GTPPTGNQPF PKKAVDVFFP
PEAQNDFPVA MQISDKHDVV FLITKYGYIH LYDLETGTCI YMNRISGETI FVTAQHEATA
GIIGVNRKGQ VLSVCVEEEN IIPYITNVLQ NPDLALRMAV RNNLAGAEEL FARKFNALFA
QGNYSEAAKV AANAPKGILR TPDTIRRFQS VPAQPGQTSP LLQYFGILLD QGQLNKYESL
ELCRPVLQQG RKQLLEKWLK EDKLECSEEL GDLVKSVDPT LALSVYLRAN VPNKVIQCFA
ETGQVQKIVL YAKKVGYTPD WIFLLRNVMR ISPDQGQQFA QMLVQDEEPL ADITQIVDVF
MEYNLIQQCT AFLLDALKNN RPSEGPLQTR LLEMNLMHAP QVADAILGNQ MFTHYDRAHI
AQLCEKAGLL QRALEHFTDL YDIKRAVVHT HLLNPEWLVN YFGSLSVEDS LECLRAMLSA
NIRQNLQICV QVASKYHEQL STQSLIELFE SFKSFEGLFY FLGSIVNFSQ DPDVHFKYIQ
AACKTGQIKE VERICRESNC YDPERVKNFL KEAKLTDQLP LIIVCDRFDF VHDLVLYLYR
NNLQKYIEIY VQKVNPSRLP VVIGGLLDVD CSEDVIKNLI LVVRGQFSTD ELVAEVEKRN
RLKLLLPWLE ARIHEGCEEP ATHNALAKIY IDSNNNPERF LRENPYYDSR VVGKYCEKRD
PHLACVAYER GQCDLELINV CNENSLFKSL SRYLVRRKDP ELWASVLLES NPYRRPLIDQ
VVQTALSETQ DPEEVSVTVK AFMTADLPNE LIELLEKIVL DNSVFSEHRN LQNLLILTAI
KADRTRVMEY INRLDNYDAP DIANIAISNE LFEEAFAIFR KFDVNTSAVQ VLIEHIGNLD
RAYEFAERCN EPAVWSQLAK AQLQKGMVKE AIDSYIKADD PSSYMEVVQA ANASGNWEEL
VKYLQMARKK ARESYVETEL IFALAKTNRL AELEEFINGP NNAHIQQVGD RCYDEKMYEA
AKLLYNNVSN FGRLASTLVH LGEYQAAVDG ARKANSTRTW KEVCFACVDG KEFRLAQMCG
LHIVVHADEL EELINYYQDR GYFEELITML EAALGLERAH MGMFTELAIL YSKFKPQKMR
EHLELFWSRV NIPKVLRAAE QAHLWAELVF LYDKYEEYDN AIITMMNHPT DAWKEGQFKD
IITKVANVEL YYKAVQFYLE FKPLLLNDLL MVLSPRLDHT RAVTFFTKVK QLPLVKPYLR
SVQNHNNKSV NESLNNLFII EEDYQALRTS IDAYDNFDNI SLAQRLEKHE LIEFRRIAAY
LFKGNNRWKQ SVELCKKDRL YKDAMQYASE SKDTELAEEL LQWFLQENKR ECFGACLFTC
YDLLRPDVVL ETAWRHNIMD FAMPYFIQVM KEYLTKVDKL DASESLRKEE EQATETQPIV
YGQPQLMLTA GPSVAVPPQA PFGYGYTAPP YGQPQPGFGY SM
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