ID A0A087R0B1_APTFO Unreviewed; 1500 AA.
AC A0A087R0B1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Pleckstrin homology domain-containing family H member 2 {ECO:0000313|EMBL:KFM06915.1};
GN ORFNames=AS27_01434 {ECO:0000313|EMBL:KFM06915.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM06915.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM06915.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM06915.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL226006; KFM06915.1; -; Genomic_DNA.
DR RefSeq; XP_009276681.1; XM_009278406.2.
DR STRING; 9233.A0A087R0B1; -.
DR GeneID; 103898187; -.
DR KEGG; afor:103898187; -.
DR CTD; 130271; -.
DR OrthoDB; 4538469at2759; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13206; FERM_C-lobe_PLEKHH1_PLEKHH2; 1.
DR CDD; cd17179; FERM_F1_PLEKHH2; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22903:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286}.
FT DOMAIN 711..805
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 819..927
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 963..1118
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1129..1463
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 195..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..172
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 195..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1500 AA; 168609 MW; 260BEA6839D63223 CRC64;
MAELSEPEGT VNWKERCLTL ESQLMKFRLQ ASKIRELLAE KMQQLEKQVI DADRQAERAF
QQVQVMEEKL KAANVQMSES ETRLYKRCQD LEILIQDKND IIQKLEQQLE EQKQIRLQEA
KIIEEKAAKI KEWVTVKLHE LEVENQNLRL INQKQTKEMK TVQSKLQEAT GKKSVTSTQK
PGECQRLSSL TFGCFSNRAR SPQPSPKFEE ISKSSSKESG YTEGKNMLEK DILETTFAGP
AHESNTGQKS LQQSSSGSEQ NKNVRTSCSS KDIDSDMSKN SCTTGSDWSS DEDGGENKGL
KSRCASTLSS HTSEENARYS RMGSEMYLTA SDDSSSLFEE ESFGVQRTQH KKLYSWQQGS
QRKGQSNPGG KCNSDFTSKK KDQDSSSDEL NKKFQSQRLD YSSSSSEANT PSPILTPALT
PKHPILATSA GSQCTTPSDS PSNLPPPKLR TPNVFSINSA LAKKHLSQPQ LSSDRMFGRN
RNAISMIRPW RPQETDIDLV DGEDTDILEK MEISCDEGVF TYDCTEAQNA EAQELCDTTK
KGASNKPPTP PLHRFPSWES RIYAVAKSGL RMSEALTMES LNKSAVSVTS YSISGLYTSL
IYKNMTTPVY TTLKGKATQI SSSPFIDESS GSEEEDSSRS SSRTSESDSR SRSGPGSPRA
MKRGVSLSSV TSESDYAIPP DAYSVDTDYS EPEQKLPKTS SSSSDNGKNE PLEKSGYLLK
MGGKVKTWKR RWFVLKGGEL LYYKSPSDVI RKPQGQIELN ASSHIERGDG KQTIQLTTEK
RTYYLTADSP NILEEWIKVL QNVLKIQAAS PLFIQPEIKP TMKGLLTKVK HGYSKRVWCT
LVGKILYYFR NQEDKFPLGQ IKLFEAKVEE VDRSCDSDED YEASSRSLLS THYTVVIHPK
DQGPTYLLIG SKHEKDTWLY HLTVAAGSTS VNVGSEFEQL ICKLLNMEGD TTSQIWRHPT
LCHSKEGIAS PLTTLPSEAL QTEAIKLFKT CQLFINAAVD SPAIDYHVSL AQSALQICLT
HPELQNEICC QLIKQTRRRH PQNQAGPIQG LQLLALCVGL FLPQHPFLWL LKLHLKKNAD
SRTEFGKYAI YCQRCVERTQ QNGDREARPS RMEILSTLLR NPYHHSLPFS IPVHFMNGIY
QVVGFDASTT VEEFLNTLNQ DTGMRKPAQS GFALFSDDPS GKDIEHCLQG NIKICDIISK
WEQASKEQHP GKCEGTRTVR LTYKNRLYFS VQVHGETDRE KLLLVYQTND QIVNGLFPVN
KELAMELTAL LAQVEIGDFE RPFSTPAGQV TSQSKSNQTL KQVLERFYPK RYRHGCSEEQ
LRQLCQRLST RWMALRGHSA ADCVRIYLTV VRKWSFFGAK LFAAKPLATS SVEKSFIWFA
VHEDGISILD YSSMRLTVTY TYKSLMTFGG YQDDFMLVVN NAQTKDKSTE KHLFAMTKPK
ILEITLLIAS YINNFHQLKG AAHHLSAPAL LTLQSGQKLK ETGSQPLLAN NRPTKCPTLL
//
