ID A0A087R306_APTFO Unreviewed; 501 AA.
AC A0A087R306;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Orexin receptor type 2 {ECO:0000256|ARBA:ARBA00015322};
DE AltName: Full=Hypocretin receptor type 2 {ECO:0000256|ARBA:ARBA00032358};
GN ORFNames=AS27_00726 {ECO:0000313|EMBL:KFM07860.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM07860.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM07860.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM07860.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; KL226067; KFM07860.1; -; Genomic_DNA.
DR RefSeq; XP_009278007.1; XM_009279732.1.
DR AlphaFoldDB; A0A087R306; -.
DR STRING; 9233.A0A087R306; -.
DR GeneID; 103899293; -.
DR KEGG; afor:103899293; -.
DR CTD; 3062; -.
DR OrthoDB; 2949325at2759; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0045177; C:apical part of cell; ISS:AgBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:AgBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016499; F:orexin receptor activity; IEA:InterPro.
DR GO; GO:0022410; P:circadian sleep/wake cycle process; IEA:InterPro.
DR GO; GO:0007631; P:feeding behavior; IEA:InterPro.
DR CDD; cd15208; 7tmA_OXR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000204; Orexin_rcpt.
DR InterPro; IPR004060; Orexin_rcpt_2.
DR PANTHER; PTHR45695:SF24; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45695; LEUCOKININ RECEPTOR-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF03827; Orexin_rec2; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01522; OREXIN2R.
DR PRINTS; PR01064; OREXINR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..366
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 501 AA; 56741 MW; 3CF1C2BE0373E3E0 CRC64;
MSGIQPEDGS PPCRNWTIGS ELNETREALL TPSSDYDDEE FLRYLWKEYL HPKEYEWALI
AGYIVVFIVA LVGNVLVCIA VWKNHHMRTV TNYFIVNLSL ADILVTITCL PATLVVDITE
TWFFGQSLCK VIPYLQTVSV SVSVLTLSCI ALDRWYAICH PLMFKSTAKR ARNSIIIIWI
VSCIIMIPQA IVMECSSVFP GLANKTTLFT VCDEHWGAEV YPKMYHTCFF LVTYMAPLCL
MVLAYLQIFR KLWCRQIPGT SSVVQKKWKP LQSSAQPRGL GQSTKSKISA VAAEIKQIHA
RRKTARMLMV VLLVFALCYL PISILNVLKR VFGMFNHADD RETVYAWFTF SHWLVYANSA
ANPIIYNFLS GKFREEFKAA FSCCFFGIRS QHDERLARGR ASTESRKSLT TQISNFDNIS
KLSEHVVLTN INTIPANGIP ATLSPLKSVE LHLHIPGMNM TSNLDEAVRV SAEDTANTEN
VEWDRFVPSI TKLTSMELQQ G
//