ID   A0A087R4L0_APTFO        Unreviewed;       984 AA.
AC   A0A087R4L0;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   22-FEB-2023, entry version 23.
DE   SubName: Full=DENN domain-containing protein 1A {ECO:0000313|EMBL:KFM08414.1};
DE   Flags: Fragment;
GN   ORFNames=AS27_13691 {ECO:0000313|EMBL:KFM08414.1};
OS   Aptenodytes forsteri (Emperor penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC   Aptenodytes.
OX   NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM08414.1, ECO:0000313|Proteomes:UP000053286};
RN   [1] {ECO:0000313|EMBL:KFM08414.1, ECO:0000313|Proteomes:UP000053286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM08414.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KL226097; KFM08414.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087R4L0; -.
DR   STRING; 9233.A0A087R4L0; -.
DR   Proteomes; UP000053286; Unassembled WGS sequence.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 6.10.140.1000; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR040032; DENND1A/B/C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR13196; DENN DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR13196:SF22; DENN DOMAIN-CONTAINING PROTEIN 1A; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   4: Predicted;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053286}.
FT   DOMAIN          1..348
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          424..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          549..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..703
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          847..866
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          872..917
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          942..984
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        445..462
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        485..499
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..519
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        677..691
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        946..963
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFM08414.1"
FT   NON_TER         984
FT                   /evidence="ECO:0000313|EMBL:KFM08414.1"
SQ   SEQUENCE   984 AA;  109160 MW;  94CC85438778C1A1 CRC64;
     DPEVRRQFPE DYSDQEVLQT LTKFCFPFYV DSHAVNQVGQ NFTFVLTDID SKQRFGFCRL
     SSGAKSCFCI LSYLPWFEVF YKLLNVLADY SAKGQDSQRS ELLETFHKLT IPEPGTSVHL
     GVHSYFTVPD IRELPSIPEN RNLTEYFVAV DVNNMLHLYA SMLYERRILI CCSKLSTLTA
     CIHGSAAMLY PMFWQHVYIP VLPPHLLDYC CAPMPYLIGI HLSLMEKVRN MALEDVVILN
     VDTNTLETPF DDLQSLPNDV VSALKNRLKK VSTTTGDGVA RAFLKAQASF FGSYRNALKI
     EPGEPITFCE ETFVSHRSAV MRQFLQNAIQ LQLFKQFIDG RLDLLNSGEG FSDVFEEEIN
     MGEYAGSDKL YHQWLSTVRK GSGAILNTVK TKANPAMKTV YKFAKDHAKM GIKEVKNRLK
     QKDIAENGCS ATPEESLPRT APSPLVEKKD PKLREDRRPI TVHFGQVRPP RPHVVKRPKS
     NIAVEGRRTS VSSPEQPQPY RALKESDSAD GEEAVSPEKS KEPLPPSPLL SSKATEINLL
     EDIFPNLEVE TQPQPLSQAK SLEDLRTPKE EGDQRCTFDY QRMDLGVSER NRIVPTMKLS
     HPYNKLWSMG HDDMAIPTKY SQSSPERPLT ALGNMPPITR RPRSRDSVLA PAEKDESNPA
     IQGNITIPRP QGRKTPELGI VPPPPAPRAS KHQTPAGPTE KPFGVGSVSL DPEIQQSINY
     SSHPSQLLSS ATSTAEMLQP VKVKTDNTGN ESDYLLNLLD PLKTASWQSS GPQQVASDFV
     PPPAAPFVQP LGYPSPARPP FLQPSPNPFT QTVPGALSVS LVRPPRGSFT PSLGHAYSSS
     FITPNSSFYP PQRPQPNIST LSMPNLFSQA PGVPPASSLL LQSHSPSPTS SLQPACLSGP
     SKTRTLQVGQ SSSKVDPKQA LALLSNEPPL IPSRPAKGLE SVLLSSKSEE TKDPFEDLLK
     KTKQDVSSTP GKVEQLRKRW ETFE
//