ID   A0A087R4V0_APTFO        Unreviewed;       823 AA.
AC   A0A087R4V0;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   ORFNames=AS27_04464 {ECO:0000313|EMBL:KFM08504.1};
OS   Aptenodytes forsteri (Emperor penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC   Aptenodytes.
OX   NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM08504.1, ECO:0000313|Proteomes:UP000053286};
RN   [1] {ECO:0000313|EMBL:KFM08504.1, ECO:0000313|Proteomes:UP000053286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM08504.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
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DR   EMBL; KL226108; KFM08504.1; -; Genomic_DNA.
DR   RefSeq; XP_009278982.1; XM_009280707.1.
DR   RefSeq; XP_009278983.1; XM_009280708.1.
DR   AlphaFoldDB; A0A087R4V0; -.
DR   STRING; 9233.A0A087R4V0; -.
DR   GeneID; 103900111; -.
DR   KEGG; afor:103900111; -.
DR   CTD; 9870; -.
DR   OrthoDB; 5480520at2759; -.
DR   Proteomes; UP000053286; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11254:SF340; APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1; 1.
DR   PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR   Pfam; PF00630; Filamin; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   REPEAT          118..158
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   DOMAIN          483..823
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          323..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        790
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   823 AA;  94354 MW;  66BD11881BB00336 CRC64;
     MFYIIGGITV SVVAFFFGIK FLSELAARIV SFFQHEDRER RGERTIYDYV RGNYLDPRSC
     KISWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HICHVELAID IPVTQEVLQE
     PNSNVVKVAF TVRRAGRYEI TVKLGGLNVA YSPYYKVFQP GMVVPSKTKI VCHFSTLVLT
     CGQQHTLQIV PRDEYDNPTS NSVSLIDEHN YSLSIHELGP QEEESSDVVF EKSVVSNRQT
     CEVFFRLTLH CRGCFHACIS YQNQPISNGD FDIIVLSENE KDVVERNVST SGVSMYFEAY
     LYDAPSYTNT QWQFPLTHLS SSQRRPSIAT EDEDEDSPSD SQTPEKVKKP KKVYCYVSPK
     QFSVKEFYLK IIPWRLFTFR VCPGTKFSYL GPDPVHKLLT LVVDDGIQPP VELSCKERNI
     LAATFIRSLH KNIGGSETFQ DKVNFFQREL RQVHMKRPHS KVTLRVSRHC LLESSFKATR
     NFSVSDWSKN FEVIFQDEEA LDWGGPRREW FELICKALFD TTNQLFTRFS DNNQALVHPN
     PGRPTYLRLK VYEFAGRLVG KCLYESSLGG AYKQLVRARF TRSFLAQIIG LRMHYKYFET
     DDPEFYKSKV CFILNNDVSE MDLVFAEEKY SKTGQLEKVV ELVTGGAQVP VNNENKILYL
     NLLAQYRLAN QVREEVDHFL KGLNKLVPEN LLAIFDENEL ELLMCGTGDI SVCDFKAHAV
     VVGGSWHFRE KVMRWFWTVV SSFTQEELAR LLQFTTGSSQ LPPGGFAALC PSFQIIAAPT
     HSTLPTAHTC FNQLCLPTYD SYEEMHKMLK LAISEGCEGF GML
//