ID A0A087R509_APTFO Unreviewed; 1184 AA.
AC A0A087R509;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Tyrosine-protein phosphatase non-receptor type {ECO:0000256|PIRNR:PIRNR000934};
DE EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR000934};
GN ORFNames=AS27_04532 {ECO:0000313|EMBL:KFM08563.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM08563.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM08563.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM08563.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|PIRNR:PIRNR000934};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000934}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649,
CC ECO:0000256|PIRNR:PIRNR000934}.
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DR EMBL; KL226108; KFM08563.1; -; Genomic_DNA.
DR RefSeq; XP_009279035.1; XM_009280760.1.
DR AlphaFoldDB; A0A087R509; -.
DR STRING; 9233.A0A087R509; -.
DR GeneID; 103900148; -.
DR CTD; 11099; -.
DR OrthoDB; 3108587at2759; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR CDD; cd17192; FERM_F1_PTPN21; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF3; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR000934};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR000934}; Hydrolase {ECO:0000256|PIRNR:PIRNR000934};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR000934};
KW Receptor {ECO:0000313|EMBL:KFM08563.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286}.
FT DOMAIN 23..308
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 906..1177
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1088..1168
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 317..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1118
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 1184 AA; 135468 MW; CF7F752C0951C84D CRC64;
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE AVAQRLELRE
ITYFSLWYYN KQNQRRWVDL DKPLKKQLDK YALEPTVYFG VVFYVPTVSQ LQQEITRYQY
YLQLKKDILE GNIPCTLEQA IHLAGLAVQA DFGDYDQYES QEFLQRFALF PVGWLQEEKI
LEEATQKVAL LHQKYRGLTP PDAEMLYMQE VERMEGYGEE TYPAKDSQGS DIFIGACLDG
IFVKHKNGRP PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRMCVAR
HKFYRLNKCS LQTQPVTVNP VRRRSSSRMS MPKPQPYMMP PPPQLHYNGH YTEPYASSQD
NLFVSNQNGY YCHSQTSLDR APHDYSGRIR NGSVYSAHST NSLNNPQHYL QPSPMSSNPS
ITGSDVLRTD YVPSHRHSAL IPPSYRPTPD YETVMRQLNR GMVHTDRQSH SMRNLNISNS
YAYSRPDALV YSQPEIREHA HIASPQSNHY PFNLNYSFHS QSPYPYPAEK RPVVGAVSVP
ELTNVQLQAQ DYPAPNIMKT QVYRPPPPYP YPRPANSTPD LSRHIYISNS NPDLITRRVH
HSVQTFQEDS LPVAHSLQEV SEPLTSARHA QLQKRNSIEI AGLTPSFEGI RIKERTMSAS
AADVALPRVI SEGSQSNILM ERTKQKESEQ EESVNCDHKK TLSDATMLIH SSEEEEFEEE
NKASTSLSPL PEDQTQLPSV MGGYSHDSVL NYPYSSVASS AGPLHILEPK LHITETEKRM
KDMSPVHLLV ESQVQRRGEG LLTPSMSESD LTTSGRYRIR KDSVKKRPVS DLLSGKKNIV
EGLPPLGGMK KNKNDAKKIG PLKLAALNGL ALTRMPLPDE GKEESTRATN DERCKVLEQR
LEQGMVFTEY ERIQKKRLID GECSIARLPE NAERNRFQDV LPYDDTRVEL VPTKENNTGY
INASHIKISV SGIEWDYIAT QGPLQNTCQD FWQMIWEQGI AIIAMVTAEE ESGREKSFRY
WPRLGSRHNT VTYGRFKITT RFRTDSGCYA TTGLKIKHLL TGQERTVWHL QYTDWPEHGC
PEDLKGFLSY LEEIQSVRRH TNSTVDPKNS NPPVLVHCSA GVGRTGVVIL SEIMIACLEH
NEMLDIPRVL DMLRQQRMMM VQTLSQYTFV YGVLIQFLKS SRLI
//
