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Database: UniProt
Entry: A0A087R963_APTFO
LinkDB: A0A087R963_APTFO
Original site: A0A087R963_APTFO 
ID   A0A087R963_APTFO        Unreviewed;       422 AA.
AC   A0A087R963;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   31-JUL-2019, entry version 24.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 2 {ECO:0000313|EMBL:KFM10017.1};
DE   Flags: Fragment;
GN   ORFNames=AS27_04869 {ECO:0000313|EMBL:KFM10017.1};
OS   Aptenodytes forsteri (Emperor penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC   Aptenodytes.
OX   NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM10017.1, ECO:0000313|Proteomes:UP000053286};
RN   [1] {ECO:0000313|EMBL:KFM10017.1, ECO:0000313|Proteomes:UP000053286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM10017.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   EMBL; KL226222; KFM10017.1; -; Genomic_DNA.
DR   Proteomes; UP000053286; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003275; K_chnl_inward-rec_Kir3.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF19; PTHR11767:SF19; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01328; KIR32CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053286};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:KFM10017.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     92    115       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    166    190       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       56    195       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      202    372       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      389    422       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    390    422       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        181    181       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFM10017.1}.
FT   NON_TER     422    422       {ECO:0000313|EMBL:KFM10017.1}.
SQ   SEQUENCE   422 AA;  48406 MW;  2C8E5C892267410A CRC64;
     VCLFLMAANV LEEDSMEQDI ESPVTIHQPK LPKQAREDLP KNINKECAKR KIQRYVRKDG
     KCNVHHGNVR ETYRYLTDIF TTLVDLKWRF NLLIFVMVYT VTWLFFGMIW WLIAYMRGDM
     DHIGDSTWTP CVSNLNGFVS AFLFSIETET TIGYGYRVIT DKCPEGIILL LVQSVLGSIV
     NAFMVGCMFV KISQPKKRAE TLVFSTNAVI SMRDGKLCLM FRVGDLRNSH IVEASIRAKL
     IKSKQTKEGE FIPLNQTDIN VGYYTGDDRL FLVSPLIISH EINQQSPFWE ISKAQLPKEE
     LEIVVILEGM VEATGMTCQA RSSYITSEIL WGYRFTPVLT LEDGFYEVDY NSFHETYETN
     TPVYSAKELA EMASRAELPL TWSVSSKLDQ HAELETEEEE KNQEDQNERN GDVANLENES
     KV
//
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