ID A0A087R9C0_APTFO Unreviewed; 2552 AA.
AC A0A087R9C0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=AS27_04935 {ECO:0000313|EMBL:KFM10074.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM10074.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM10074.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM10074.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR EMBL; KL226222; KFM10074.1; -; Genomic_DNA.
DR RefSeq; XP_009281310.1; XM_009283035.2.
DR STRING; 9233.A0A087R9C0; -.
DR MEROPS; C19.017; -.
DR GeneID; 103902035; -.
DR KEGG; afor:103902035; -.
DR CTD; 8239; -.
DR OrthoDB; 6206at2759; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021905; DUF3517.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF827; UBIQUITINYL HYDROLASE 1; 1.
DR Pfam; PF12030; DUF3517; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:KFM10074.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286}.
FT DOMAIN 1557..1955
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1595..1619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2474..2552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1604..1619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2501..2515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2522..2552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2552 AA; 290232 MW; D1658112C61ABCE3 CRC64;
MTATTRGSPV GGNDSQGQAP DGQSQPPLQQ NQTSSPDSSN ENSPATPPDE QGQGDAPPQL
EDEEPAFPHT DLAKLDDMIN RPRWVVPVLP KGELEVLLEA AIDLSKKSLD VKSEACQRFF
RDGLTISFTK ILTDEAVSGW KFEIHRCIIN NTHRLVELCV AKLSQDWFPL LELLAMALNP
HCKFHLYNGT RPSETVPAGV QLAEDELYAR PPDPRSPKGW LVDLINKFGT LNGFQILHDR
FMSGSALNVQ IIAALIKPFG QCYEFLTLHT VKKYFLPIIE MVPQFLENLT DDELKKEAKN
EAKNDALSMI IKSLKNLASR VPGQEETVKN LEIFRLKMIL RLLQISSFNG KMNALNEVNK
VISSVSYYTH RHGNPEEEEW LTAERMAEWI QQNNILSIVL RDSLHQPQYV EKLEKILRFV
IKEKALTLQD LDNIWAAQAG KHEAIVKNVH DLLAKLAWDF SPEQLDHLFD CFKASWTNAS
KKQREKLLEL IRRLAEDDKD GVMAHKVLNL LWNLAHSDDV PVDIMDQALS AHIKILDYSC
SQDRDTQKIQ WIDRFIEELR TNDKWVIPAL KQIREICSLF GEAPQNLSQT QRSPHVFYRH
DLINQLQHNH ALVTLVAENL SAYMESMRQY AKEHGEYDPQ TVRPGSRYSH VQEVQERLNF
LRFLLKDGQL WLCAPQAKQI WKCLAENAVY LCDREACFKW YSKLMGDEPD LDPDINKDFF
ENNVLQLDPS LLTENGMKCF ERFFKAVNCR EGKLVAKRRA YMMDDLELIG LDYLWRVVIQ
GNDDIANRAI DLLKEIYTNL GPRLQVNQVV IHEDFIQSCF DRLKASYDTL CVLDGDKDSI
NCARQEAIRM VRVLTVLREY INECDSDYHE ERTILPMSRA FRGKHITLVV RFPNQGRQVE
DLDIWSHTND TIGQVRRCIL NRIKANSAHT KVELFIGGEL VDPADDRKLI GQLNLKDKTL
ITAKLTQINS NMPSSPDSSS DSSTGSPGNH GNHYSDGPNP EVESCLPGVI MSLHPRYISF
LWQVADLGSS LNMPPLRDGA RVLMKLMPPD NTTVEKLRAI CLDHAKLGES SLSPSLDSLF
FGPSASQVLY LTEVVYALLM PASAPLGEDA SDFQYNFLKS GGLPLVLSML TRNNFLPNAD
METRRGAYLN ALKIAKLLLT AIGYGHVRAV AEACQPVVEG TSTISPINQA THDQAVVLQN
ALQNIPNPTS ECMLRNVAIR LAQQISDEAS KYIPDICVIR AVQKIVWASG CGSVQLVFSS
NEEISKIYEK TNAGNEPDME DEQVCCEALE VMTLCFALIP TALDALSKEK AWQTFIIDLL
LHCHSKTVRQ MAQEQFFLMA TRCCMGQRPL LFFITLLFTV LGSTARERAK HSGDYFTLLR
HLLNYAYNSN INVPNAEVLL NNEIDWLKRI RDEVKRTGET GVEETILEGH LGVTKELLAF
QTPEKKYHIG CEKGGANLIK ELIDDFIFPA SNVYLQYMRN GELPAEQAIP VCSSPATINA
GFELLVALAV GCVRNLKQIV DTLTEMYYIG TAITTCEALT EWEYLPPVGP RPPKGFVGLK
NAGATCYMNS VIQQLYMIPA IRNGILAIEG TGSDVDDDMS GDEKQDNESN VDPRDDVFGY
PHQYEDKPAL SKTEDRKEYN IGVLRHLQVI FGHLAASRLQ YYVPRGFWKQ FRLWGEPVNL
REQHDALEFF NSLVDSLDEA LKALGHPAML SKVLGGSFAD QKICQGCPHR YECEESFTTL
NVDIRNHQNL LDSLEQYVKG DLLEGANAYH CEKCNKKVDT VKRLLIKKLP PVLAIQLKRF
DYDWERECAI KFNDYFEFPR ELDMEPYTVA GVAKLEGDDV NPENQIIQNE QSENEHSGST
KYRLVGVLVH SGQASGGHYY SYIIQRNGGD GEKNRWYKFD DGDVTECKMD DDEEMKNQCF
GGEYMGEVFD HMMKRMSYRR QKRWWNAYIL FYERMDTIDK DNELIKYISE LAITTKPHQI
KMPSAIERSV RKQNVQFMHN RMQYSLEYFQ FIKKLLTCNS VYLNPPPGQD HLLPEAEEIT
MISIQLAARF LFTTGFHTKK IVRGPASDWY DALCILLRHS KNVRFWFAHN VLFNVSNRFS
EYLLECPSAE VRGAFAKLIV FIAHFSLQDG PCPSPFASPG PSSQAYDNLS LSDHLLRAVL
NLLRREVSEH GRHLQQYFNL FVMYANLGVA EKTQLLKLNV PATFMLVALD EGPGPPIKYQ
YAELGKLYTV VSQLIRCCNV SSRMQSSING NPPLANPYGD PNLSQPIMAL QQNVADILFV
RTSYVKKIIE DCSNSEETIK LLRFCCWENP QFSSTVLSEL LWQVAYSYTY ELRPYLDLLL
QILLIEDSWQ THRIHNALKG IPDDRDGLFD TIQRSKNHYQ KRAYQCIKCM VALFSNCPVA
YQILQSNGDL KRKWTWAVEW LGDELERRPY TGNPQYTYNN WSPPIQSNET SNGYFLERSH
SARMTLAKAC ELCPEEEPDD PDAPDEHESS PPEDAPLYPH SPGSQYQQNN HVHGQPYTGP
AAHHMNNPQR TGQRAQENYE GSEEVSPPQT KD
//
