ID   A0A087RBL1_APTFO        Unreviewed;       862 AA.
AC   A0A087RBL1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
DE   Flags: Fragment;
GN   ORFNames=AS27_13800 {ECO:0000313|EMBL:KFM10865.1};
OS   Aptenodytes forsteri (Emperor penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC   Aptenodytes.
OX   NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM10865.1, ECO:0000313|Proteomes:UP000053286};
RN   [1] {ECO:0000313|EMBL:KFM10865.1, ECO:0000313|Proteomes:UP000053286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM10865.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361199};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR   EMBL; KL226279; KFM10865.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087RBL1; -.
DR   STRING; 9233.A0A087RBL1; -.
DR   Proteomes; UP000053286; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd11666; GH38N_Man2A1; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF70; ALPHA-MANNOSIDASE 2; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW   Hydrolase {ECO:0000256|RuleBase:RU361199};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361199};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT   DOMAIN          372..459
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
FT   NON_TER         862
FT                   /evidence="ECO:0000313|EMBL:KFM10865.1"
SQ   SEQUENCE   862 AA;  100004 MW;  107C57584AFC2844 CRC64;
     MLDVYDILPF DNPDGGVWKQ GFDITYNENE WDSEPLQVFV VPHSHNDPGW LKTFDDYFRD
     QTQHILNNMV IKLQEDNRRK FMWSEISYFS KWWDGIDSQK KDAVKRLIKD GQFEIVTGGW
     VMPDEASPHY FALVDQLIEG HQWLEKSLGV KPKSGWAIDP FGHSPTMAYL LKRTGFSNML
     IQRVHYSVKK HFATQKTLEF FWRQNWDLGS STDILCHMMP FYSYDVPHTC GPDPKICCQF
     DFKRLPGGRV SCPWRVPPEA IHAGNVQHRA WMILDQYRKK SKLFRTKVLL APLGDDFRYA
     ESSEWDQQYQ NYQKLFDYMN SHPEWHVKAQ FGTLSDYFEA LRKESSLGEE GSNSFFPVLS
     GDFFTYADRD HHYWSGYFTS RPFYKRLDRL LESYLRAAEI LYSLALVQSS RSEKLSVFPS
     VDNYKLLTEA RRNLGLFQHH DAITGTSKDW VVVDYGTRLF HSIMNLKKVI IDSAHILILK
     DNHAYNYDTS TPFLKMDDVQ SSQDSLPRKT VIKLTLQPRY LLIYNPTEQE RFSVVSVNVN
     SPRVKLLSPL GKPVTVQISA VWDGATTVSH EAYQIFFVAH LPPLGLGVYQ LLEVQSSEAV
     LADYNIYMKN SRQEKPDRLF NIKEMQNSVD NIILENSYMK LWFSGMSGLL EKMNTKDDGK
     NHQMKVEFAW YGTTSNRDKS GAYLFLPDGD AKPYIFTDPP IIRVAHGRIF SEVVCFFHHV
     THTMRLYKVQ GLEGQSLEVS NIVDIRGEYN RELAMRISSD INSQNRFYTD LNGYQIQPRL
     TMSKLPLQAN IYPMTTMAYI QDVGVRLTLH SAQSLGVASL KNGQLEVIMD RRLMQDDNRG
     LGQGVQDNKI TANIFRLLLE RR
//