ID   A0A087RDD5_APTFO        Unreviewed;      1103 AA.
AC   A0A087RDD5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 8 {ECO:0000313|EMBL:KFM11489.1};
GN   ORFNames=AS27_07212 {ECO:0000313|EMBL:KFM11489.1};
OS   Aptenodytes forsteri (Emperor penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC   Aptenodytes.
OX   NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM11489.1, ECO:0000313|Proteomes:UP000053286};
RN   [1] {ECO:0000313|EMBL:KFM11489.1, ECO:0000313|Proteomes:UP000053286}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM11489.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KL226309; KFM11489.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087RDD5; -.
DR   SMR; A0A087RDD5; -.
DR   STRING; 9233.A0A087RDD5; -.
DR   Proteomes; UP000053286; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR041491; TRPM_SLOG.
DR   PANTHER; PTHR13800:SF9; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8; 1.
DR   PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF18139; LSDAT_euk; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KFM11489.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT   TRANSMEM        692..711
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        723..756
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        768..786
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        798..817
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        823..843
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        864..883
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        954..983
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1004..1024
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          116..375
FT                   /note="TRPM SLOG"
FT                   /evidence="ECO:0000259|Pfam:PF18139"
FT   DOMAIN          742..988
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
SQ   SEQUENCE   1103 AA;  127639 MW;  C6D5C230A8630312 CRC64;
     MVFQVSMGTM RHRRNGNFES SRLLYSSMSR SIDVSCSDAD LANFIQENFK KRECVFFTKD
     TKSTGNLCKC GYPENQHIEG TQINTNEKWN YKKHTKELPT DAFGDIQFEN MGKRGKYIRL
     SCDTDSETLY DLMTQHWHLK TPNLVISVTG GAKNFALKPR MRKIFSRLIY IAQSKGAWIF
     TGGTHYGLMK YIGEVVRDNT ISRSSEENVV AIGIAAWGMI SNRESLIRSD DNDGYYLAHY
     IMDDLKRDPL YCLDNNHTHL LLVDNGTHGH PTIEAKVRTQ LEKYISERVI PESNYGGKIP
     IVCFAQGGGK ETLKSINVAI KSKIPCVVVE GSGRIADVIA SLMEAEGTLA SSCVKESLLR
     YLPHTISRLS EEETESWIKW IKEVLENPHL LTVIKIEEAG DEIVSNAISF ALYKGNTNEH
     DRDNWNGQLK LLLEWNQLDL ASDEIFTNDR NWESADLQDV MFTALVKDRP KFVRLFLENG
     LNLRKFLTTE VLRELYTKNF SSLVFKNLQI AKNSYNDALL TFAWKMVEDF RRGLKRDDKN
     SKDEMEIHLS DECPITRHPL QALFIWSVLQ NKKELSKVIW EQTRGCTLAA LGASKLLKSM
     AKVKNDINAA GESEELANEY ETRAVELFTE CYSNDEDLAE QLLTYSCEAW GGSNCLELAV
     EAKDQQFIAQ PGVQNFLSKQ WYGEISRDTK NWKIILCLFF FPLIGCGFIS FRKKPVEKSK
     KLFLYYVSFF TSPFVVFSWN VIFYIAFLLV FAYVLLMDFQ KEPTILEMIL YVLVFILLCD
     EVRQWYMNGS KYFSDLWNVM DTLAIFYFIA GIVFRLHSSD ESSWYSGRVI FCLDYIVFTL
     RLIHIFTVSR NLGPKIIMLQ RMMIDVFFFL FLFAVWMVAF GVARQGILRK NEHRWEWIFR
     SVIYEPYLAM FGQYPDDVDG TTYNFDRCTF SGNESKPLCV ELDANNQPRF PEWITIPLVC
     IYMLSTNILL VNLLVAMFGY TVGSVQENND QVWKFQRYFL VQEYCSRLTI PFPFVIFAYI
     FMVMRKCFKC CCKKESKEPS MCCSKNEDDE ILAWEAVMKE NYLVKTNTKA NDPSEEMVHR
     FRQLDAKLSD LKGLLKEISS KIK
//