ID A0A087RF39_APTFO Unreviewed; 830 AA.
AC A0A087RF39;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Rap guanine nucleotide exchange factor 6 {ECO:0000313|EMBL:KFM12093.1};
GN ORFNames=AS27_12084 {ECO:0000313|EMBL:KFM12093.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM12093.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM12093.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM12093.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR EMBL; KL226335; KFM12093.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087RF39; -.
DR STRING; 9233.A0A087RF39; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR PANTHER; PTHR45161:SF4; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286}.
FT DOMAIN 282..382
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 414..527
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 532..602
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 752..830
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 173..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..243
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 93940 MW; 9CC8F8BEE7B62B15 CRC64;
MTSPVDPKIK QALRKKPSER TAEDLNTIYS FLHGLDILSH FREHQLRIMS SSARYERYKG
NQVLFCSETI ARCWYILLSG SVLMKDSMFL PPCSFGKQSG GKRGCECIIL EPSEMIVVEN
SKDNEENILQ REVPLRQSRR RFRKINQRGE RQTITDNVDS SSYLSLPADL TKMHLTDNPH
PQVTHVPSSQ SGCSIASDSG SSSLSDIYQA TESEMGDVDL TGLPEAPVDS EDEEEEEDED
IDRTSDPLLG RDVVRECLEK EPADKTDDDI EQLLEFMHQL PAFANMTMSV RRELCSVMIF
EVVEQAGAII LEDSQELDSW YVILNGTVEI TYPDGKSESL CMGNSFGITP SLDKQYMNGV
VRTKVDDCQF VCIAQQDYWR ILNHVEKNTH KVEEEGEIVM VKEHRELDRS GTRKGHIVIK
ATPERLIMHL IEEHSIVDPT YIEDFLLTYR TFLTSPLEVG NKLLEWFTVD SLRDKVTRVV
LLWVNNHFND FEGDPAMTRF LEEFEKNLED TKMKGHLRLL NIACAAKAKW RQITLQKPSR
DSPLFFSLLG GSDKGFGIFV ETVEMGSKAA EAGLKRGDQI MEVNGQNFEN ITFVKALEIL
RNNTHLSITV KTNIFVFKEL LCRIGQEKNG IPHIPKIAEK KNNRYSIPDM PGDVEQMFPR
EKGNKKMKAN TVSGGRNRIR KILDKTRFSI LPPKLFSDGS VSQSQDDSIV GTRQCRHSLA
IMPIPGTLSS SSPDLLQPTT SILDFSNPSD IPDQVIRVFK ADQQSCYIII SKDTTAKEVV
SHAVHEFNLT GAPETYSLCE VSVSPEGVIK QRRLPDQFSK LADRIQLNGR
//
