ID A0A087RIM6_APTFO Unreviewed; 215 AA.
AC A0A087RIM6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Somatotropin {ECO:0000313|EMBL:KFM13330.1};
DE Flags: Fragment;
GN ORFNames=AS27_06509 {ECO:0000313|EMBL:KFM13330.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM13330.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM13330.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM13330.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU003618}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000256|ARBA:ARBA00008474, ECO:0000256|RuleBase:RU003618}.
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DR EMBL; KL226388; KFM13330.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087RIM6; -.
DR STRING; 9233.A0A087RIM6; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; ISS:AgBase.
DR GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:AgBase.
DR GO; GO:0010629; P:negative regulation of gene expression; ISS:AgBase.
DR GO; GO:0035846; P:oviduct epithelium development; ISS:AgBase.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
DR CDD; cd10285; somatotropin_like; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR034975; Somatotropin.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417:SF2; SOMATOTROPIN; 1.
DR PANTHER; PTHR11417; SOMATOTROPIN,PROLACTIN; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU003618};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..215
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001828658"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM13330.1"
FT NON_TER 215
FT /evidence="ECO:0000313|EMBL:KFM13330.1"
SQ SEQUENCE 215 AA; 24644 MW; 23161274E4BD530F CRC64;
AGSWFSPLLI AVITLGLQWP QEAATFPAMP LSNLFANAVL RAQHLHLLAA ETYKEFERTY
IPEDQRHANK NSQAAFCYSE TIPAPTGKDD AQQKSDMELL RFSLVLIQSW LTPVQYLSKV
FTNNLVFGTS DRVYEKLKDL EEGIQALMRE LEDRSPRGPQ ILKPTYDKFD IHLRNEDALL
KNYGLLSCFK KDLHKVETYL KVMKCRRFGE GNCTI
//
