ID A0A087RK93_APTFO Unreviewed; 1229 AA.
AC A0A087RK93;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 03-MAY-2023, entry version 24.
DE SubName: Full=DENN domain-containing protein 5A {ECO:0000313|EMBL:KFM13897.1};
DE Flags: Fragment;
GN ORFNames=AS27_14517 {ECO:0000313|EMBL:KFM13897.1};
OS Aptenodytes forsteri (Emperor penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae;
OC Aptenodytes.
OX NCBI_TaxID=9233 {ECO:0000313|EMBL:KFM13897.1, ECO:0000313|Proteomes:UP000053286};
RN [1] {ECO:0000313|EMBL:KFM13897.1, ECO:0000313|Proteomes:UP000053286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS27 {ECO:0000313|EMBL:KFM13897.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; KL226410; KFM13897.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087RK93; -.
DR STRING; 9233.A0A087RK93; -.
DR Proteomes; UP000053286; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17690; RUN1_DENND5A; 1.
DR CDD; cd17692; RUN2_DENND5A; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR047294; RUN1_DENND5A.
DR InterPro; IPR047295; RUN2_DENND5A.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070:SF2; DENN DOMAIN-CONTAINING PROTEIN 5A; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000053286};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..540
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 729..892
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 896..1004
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1076..1224
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 623..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFM13897.1"
FT NON_TER 1229
FT /evidence="ECO:0000313|EMBL:KFM13897.1"
SQ SEQUENCE 1229 AA; 141070 MW; 173168046075B16F CRC64;
AGENFEQTPL RRTFKSKVLA RYPENVEWNP FDQDAVGMLC MPKGLAFKTQ ADSREPQFHS
FIITREDGSR TFGFSLTFFE EVTSKQICSA MQTLYHMHNA EYDILHTPPT NDKDSCSSTG
DCNGTSVSKL QRFNSYDISR DTLYVSKCIC LITPMSFMKA CKKVLEQLHQ AVTSPQPPPL
PLESYIYNIL YEVPLPPAGR SLKFSGVYGP IICQRPSTSE LPLFDFPVKE VFELLGVENV
VQLFTCALLE FQILLYSQHY QRLMTVAETI TALMFPFQWQ HVYVPILPAS LLHFLDAPVP
YLMGLHSNGL DDRSKLELPQ EANLCFVDVD NHFIELPEDL PQFPNKLEFI QEISEILTAF
GIPPEGNLHC SESASKMKSL RACDLVSDKR NGNIAGSPLN SYELLKENET IARLQALVKR
TGVSLEKLEV REETSSKKDL KIQCDEEEFK IYQLNIQIRE VFANRFTQMF ADYEVFVIQP
SQDKESWFTN REQMQNFDKA SFLSDQPEPY LPFLSRFLET QMFASFIDNK IMCHDEDDKD
PVLRVFDSRV DKIRLLNVRT PTLRTSMYQK CTTVDEAEKS IELRLAKIDH TAVHPHLLDM
KIGQGKYELG FFPKLQSDVL STGPASNKWT KRNAPAQWRR KDRQKQHTEH LRLDNDQREK
YIQEARNLGS TIRQPKLSNL SPSVIAQTNW KFVEGLLKEC RNKTKRMLVE KMGREAVELG
HGEVNITGVE ENTLIASLCD LLERIWSHGL QVKQGKSALW SHLLHYLENR QRKTTSGSFS
TSGILLDSER RKSDTSPAMS PLRISLIQDM RHIQNISEIK TDVGKARAWV RLSMEKKLLS
RHLKQLLSDH ELTKKLYKRY AFLRCDDEKE QFLYHLLSFN AVDYFCFTNV FTTILIPYHI
LIVPSKKLGG SMFTANPWIC ISGELGETGV LQIPRNILEM TFECQNLGKL TTVQIGHDNS
GLYAKWLVEY VMVRNEITGH TYKFPCGRWL GKGMDDGSLE RILVGELLTS HTEVDERQCR
TPPLQQSPSM IRRFVTISPN NKPKLNTGQI QEAIGEAVNG IVKHFHKPEK ERGSLTLLLC
GESGLVSALE QVFQHGFKSP RLFKNVFIWD FLEKAQTYYE TLEQNEMVPE ENWQTRARNF
CRFITAINNT PRNIGKDGKF QMLVCLGARD HLLHHWIALL TDCPITAQMY EDTALIKDHT
LVNSLIRVLQ TLQEFNITLE ASLVKGIDI
//
