ID   A0A087SK67_AUXPR        Unreviewed;       930 AA.
AC   A0A087SK67;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Zinc-metallopeptidase, peroxisomal {ECO:0000313|EMBL:KFM26121.1};
GN   ORFNames=F751_6272 {ECO:0000313|EMBL:KFM26121.1};
OS   Auxenochlorella protothecoides (Green microalga) (Chlorella
OS   protothecoides).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC   Chlorellales; Chlorellaceae; Auxenochlorella.
OX   NCBI_TaxID=3075 {ECO:0000313|EMBL:KFM26121.1, ECO:0000313|Proteomes:UP000028924};
RN   [1] {ECO:0000313|EMBL:KFM26121.1, ECO:0000313|Proteomes:UP000028924}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0710 {ECO:0000313|EMBL:KFM26121.1,
RC   ECO:0000313|Proteomes:UP000028924};
RX   PubMed=25012212; DOI=10.1186/1471-2164-15-582;
RA   Gao C., Wang Y., Shen Y., Yan D., He X., Dai J., Wu Q.;
RT   "Oil accumulation mechanisms of the oleaginous microalga Chlorella
RT   protothecoides revealed through its genome, transcriptomes, and
RT   proteomes.";
RL   BMC Genomics 15:582-582(2014).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; KL662126; KFM26121.1; -; Genomic_DNA.
DR   RefSeq; XP_011399017.1; XM_011400715.1.
DR   AlphaFoldDB; A0A087SK67; -.
DR   STRING; 3075.A0A087SK67; -.
DR   GeneID; 23617663; -.
DR   KEGG; apro:F751_6272; -.
DR   eggNOG; KOG0959; Eukaryota.
DR   OrthoDB; 129328at2759; -.
DR   Proteomes; UP000028924; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 6.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028924};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          39..89
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          167..318
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          319..610
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          620..800
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   930 AA;  102986 MW;  C2FA8F66893D804F CRC64;
     MVHARESTDL GGGAPGLLRC PTTDENGYRF VKLDNGLQVL LVHDPKTDKA AVACDVRVGS
     LSDPDDLPGL AHFLEHMLFY SSEKYPVEDE YRFAQFFICP LISRDGVDRE AHAVDSEHGK
     NLNSDAWKAL QLWKHTANPD HPFSRFATGN LETLLDGPAR KNVEVHTRLK EFYEKHYCSQ
     LMRAVIIGRE SLDDLQALAS SAFGPVPCRG LRAPSFSPEA TPRAGLLMKA VPERSGHTLE
     LQWRVEPELK HYDAAPCQYF SHLLGDEGEG SLFALLKARG WATDLCAGES GTSFSAASIF
     MVRIGLTDAG QEHVPELRFD FAEKMAPSSY ATTLAGAMQV YGRHDLLLAI HHVPQRYDPE
     LLDTVLSTLC PSEARVLWAS SSFQVPTDCP LKEPWYGTAH SAGPLPAEWL THWEAAWRGE
     GAALGDKDGH RFCGMHLPPP NPYIPSRFDL IKESSSSPAK IHATPLYTLW HRPETGFKVP
     KTAIYLHLRM PEAYLTPRAA VSTQLISRLL TDKLSEVAYP AELAGLHYGV RATTSGMLLS
     FWGHSHTLPR LVQTVLDSLL EFEVLPDRFE LAKEHQAKDY ANMRHEQPYQ HGLYLLSVGL
     EARRWHVRDY EAVLPGVMGD SLRAFQTAML GTVRIDALIA GNVPAADARA LLQALEARLL
     AGRCSPLPAS QRTEARVVAL PSPMRAVHAV PGPNPANDNS AVVVAFQAGR DDVRRNALVD
     LVGHLGKREA FHTLRTVEQL GYITHLSAFW TLTVSNILVL IQSSAHSARY LQSRIDAFLP
     KLADSLRGMP AEEYAAHVEE LAKAKLEKPK RLRDAVNTDW SEIDDGTLRF PRKELEAAAV
     RSITQEELVA FFEARESRGY LRVLSFWLLD TVVNPRTRRS YSVLVEGNVK EPAPEAAGSK
     ASAAPPTADE VLVSDQYSFK RGQALYASFL
//