ID A0A087V392_BALRE Unreviewed; 755 AA.
AC A0A087V392;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Nibrin {ECO:0000256|ARBA:ARBA00020013};
DE Flags: Fragment;
GN ORFNames=N312_09000 {ECO:0000313|EMBL:KFO07084.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO07084.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO07084.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO07084.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KL478249; KFO07084.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087V392; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd17741; BRCT_nibrin; 1.
DR CDD; cd22667; FHA_NBN; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.10980; Nibrin, BRCT2 domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR040227; Nibrin-rel.
DR InterPro; IPR032429; Nibrin_BRCT2.
DR InterPro; IPR043014; Nibrin_BRCT2_sf.
DR InterPro; IPR013908; Nibrin_C.
DR InterPro; IPR016592; Nibrin_met.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR12162:SF0; NIBRIN; 1.
DR PANTHER; PTHR12162; NIBRIN-RELATED; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF08599; Nbs1_C; 1.
DR Pfam; PF16508; NIBRIN_BRCT_II; 1.
DR PIRSF; PIRSF011869; Nibrin_animal; 1.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM01348; Nbs1_C; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 12..71
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 387..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO07084.1"
FT NON_TER 755
FT /evidence="ECO:0000313|EMBL:KFO07084.1"
SQ SEQUENCE 755 AA; 83616 MW; 202F2737D89BE0EB CRC64;
GEPYRLLSGT EYVVGRKNSA ILIQDDQSIS RSHAVLTVSR PETTPSQSPS VPILTVTDTS
KYGTFVNGSK LNGSSVSLQP GDRINFGVFE SKFRVEYEPL VVCSSCLDVA QKTALNQAIQ
QLGGLVVNEW TKECTHLVML SVKVTVKTIC ALICGRPIIK PEFFVELIKA IQSRQQLPNH
GSFYPPVDEP SIGAEKLDLS ERHERKKIFS GKTFVFLTAK QHKKLGPAVI LGGGEAKLMM
EGRKETSLLI SPEVCVVDVD LTNSQIPGSM RNWTDSILTV LQSKDLRAIP EAEIGLAVIF
MSTEKYCNPQ KQPGNKAVTK STPASAVVGR AISQSLAVDE TIMSTAADDS AVYVADAEIE
EQTCMETVNT PQMSRSGKMA FQDITSVKKN PSISGNVNAG TSISRVNRTP GFSQKSHPDS
PSKISEAGKP SECASRHQSN SITNYFQVAR KRVRVEEEET SVPKLAKLEE RSSPASKCTK
PTTSSVWNSE SEQHPKENNI LDPNPNFALE DTSLKLMGES GKLASDKTDT KITFSEQHAP
KKRKELDDLS EDTEALEIVF GSRDLDWEDQ MANQDQEAQG NIRKKRCLEA KGSQIPEVNV
KQRAENKILK EEELESVLSS EMESEIKEES PVLVRNLLIN HNKLQDDSSN LPSRLLLTEF
RSLVVSHPAQ NSQLTGNTSY GGKKNFKIFK KVTYPGAGQL PYIIGGSDLI AHHARKNSEL
EDWLRQEMEE QNRHAREESL ADDLFRYDPN IKRRR
//
