ID A0A087V903_BALRE Unreviewed; 1537 AA.
AC A0A087V903;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
DE Flags: Fragment;
GN ORFNames=N312_12178 {ECO:0000313|EMBL:KFO09095.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO09095.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO09095.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO09095.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR EMBL; KL484373; KFO09095.1; -; Genomic_DNA.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 7.
DR CDD; cd14617; R-PTPc-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR Pfam; PF00041; fn3; 11.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 12.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 11.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:KFO09095.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT DOMAIN 9..101
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 182..269
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 270..360
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 449..541
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 803..896
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 897..988
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1243..1503
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1421..1494
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO09095.1"
FT NON_TER 1537
FT /evidence="ECO:0000313|EMBL:KFO09095.1"
SQ SEQUENCE 1537 AA; 173222 MW; 0897AAEA2FFA2F3B CRC64;
CCTFTAPEPV LQLRVKHANE SSLSVMWMTP VAEWDSYVVS LGDRDLAVIK KGLAKEAKEF
TFTDLVPGRK YTATITTISG ILSNWTSVEG RTVPAQVTGL TVASQGSTNS LFTNWTRALG
DVDSYQVLLI HENVVIKNET VPSETNRYHF YPLKPGGLYS VVVTTVSGGI SSRQTISEGR
TVPSSVTGVT LNNSGRSDYL SVSWLPASGD VDSYLVTLSH DDQIVQTLTV SKSFSECSFS
SLTPGTLYNV MITTKSGKYE NYSFGQERTV PSSVQGLTVS NSARSDYLKV SWLHASGYFD
NYEVIIKNNN DFIQTKSVPK DENECVFTNL VPGRQYSVTV STRSGKYETS ERVYGRTMPE
SVKELTLSNR STEDLQVTWS KAEGDVDKYE IQLLFNDMKI FPPIFLGNTI EEYWFTALTP
GRLYKILVLT ISGDAQRATF IEGLTIPSAV RNIHVSPNGM TNSLKVSWTP GAGDVDSYTV
IIFQQNHQLD SQSVSKHVSE HMFHKLEAGE QYQVVVQSNS GALHNSLAAF GRTIPASVQE
LLAHHAYSSH SLLVTWQKAP GVAERYDILL LNEQGILLSN KSEPATAKQH KFEDLLAGKK
YKIQVLTVSG GLFSKRAETV GRTVPAAVTN LKVIENTTDR LSFSWTTSQG ELDSYDIFLY
NPDKSLHDRM SGEQQLQECS FQNLRQGRMY RMVIVTHSGD LTNESSVFGR TVPAPVVGLK
ASNRNMTDSL WFTWGPAAGD VDFYELNLYN PNGTQKETWH RKDLKEWHFQ GLVPGRKYTL
VVVTHSGDLT NTANAEGRTA PSPPNTVSFT DVANTSLSIT WLGPPDWTDY DDFELQWLPK
DPLTVFNPYS SSKSKVRIIY GLRPGRLYEF SVRTVSGDSW KTYSQSQSAN VRTKPDKIQS
LHCRPQTSTA IACSWTPPDS DFDGYSVECK KMDTREVEFS KRIEKDKSVL NIMTLVPHKR
YLVSIKVHSA DMTSEVVEDS TITMIDRPPQ PPPDIRVNKK EVLITKSSIN FTFNCSWFSD
TNGAVKYFTV VVREADGSEG PKPDEQHPLP SYLEYKHNDS IRIYQTNYFA SRCAENPDSD
YKSFDIKLGG EMENLGGRCD PDQQKFCDGP LKPRTAYRIS IRAFTQLFSE DPKELPKPLF
ADTFFSLPIT TEAEPLFGVI EGVSAGLFLI VMLVAVTALF VCRQKVSNGH ERPTARLSIR
RDRPLSVHLN LGQKGNRKTS SPIKVSHFEA HFTKLQADSN YLLSKEYEDL KDVGRNQTCD
IALLPENRGK NRYNNILPYD TSRVKLSNVD DDPCSDYINA SYIPGNNFRR EYIATQGPLP
GTKDEFWKMA WEQNVHNIVM VTQCVEKGRV KCDHYWPLDQ DSLYYGDLIV EMLSESVLPE
WTIREFKICS EEQLDSTRLI RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRTPDTGPT
IVHCSAGVGR TGTFIALDRI LQQLDSKDTV DIYAAVHDLR LHRVHMVQTE CQYVYLHQCV
RDVLRARKLR SEQENPLFPI YENVNPEYHR DAVYSRH
//
