ID A0A087V9X6_BALRE Unreviewed; 786 AA.
AC A0A087V9X6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Ras GTPase-activating protein 2 {ECO:0000313|EMBL:KFO09418.1};
DE Flags: Fragment;
GN ORFNames=N312_07614 {ECO:0000313|EMBL:KFO09418.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO09418.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO09418.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO09418.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL485404; KFO09418.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087V9X6; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd08401; C2A_RasA2_RasA3; 1.
DR CDD; cd04010; C2B_RasA3; 1.
DR CDD; cd13370; PH_GAP1m_mammal-like; 1.
DR CDD; cd05394; RasGAP_RASA2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037773; RASA2_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF21; RAS GTPASE-ACTIVATING PROTEIN 2; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..89
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 100..240
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 306..500
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 555..656
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO09418.1"
FT NON_TER 786
FT /evidence="ECO:0000313|EMBL:KFO09418.1"
SQ SEQUENCE 786 AA; 90663 MW; 4BED9BC223142D9E CRC64;
DAKHLVPNKM RDFFCTINLD QEEVFRTQVV EKSLSPYFGE EFFFEIPRTF QWLSFYIYDK
SVLQKDLRIG KVSIKKEDLC NYTGKENWFM LQPVDSNSEV QGKVHLELKL NELITDNGSV
CQQLVVHIKE CHGLPLINGQ NCDPYATVSL VGPCRNDQKK TKVKKKTSNP QFNETFYFEV
TRSSSYTKKS QFQVEEEDIE KLEVRVDLWN NGNLVQDIFL GEIKVPVKVL RNDSFQAWYL
LQPRENGNKS SKTDDLGSLR LNICYTEDCV LPSEYYTSLR NLLLKSSDVQ PISASAAYIL
SEVCRDKYDA VLPLVRLLLH HHKLVPFVAA VAELDLKDTQ EANTIFRGNS LATRCVDEMM
KIVGKHYLKV TLKPVIDEIC ESPKPCEIDP IKLREGDNVE INMENLRYYV DKVFREIVRS
SISCPTLMCD VFYSLRHLAA KRFPNDPHVQ YSAVSSFVFL RFFAVAVVSP HTFHLRPHHP
DAQTSRTLTL ISKAIQTLGS WGSLTKSKLS SFKETFMCEF FKTFQEEKFT ESVKKFLDDV
SSTESKEPSG LSEPVHLKEG EMYKRAQGRT RIGKKNFKKR WFCLTSREFT YHKQQDKEPI
FTIPIKNILA VEKLDESSFN KKNMFQVLHG EKPLYIQANN CVEASEWIEA LCRVTRCNPK
RLSFYHPSAF LNGNWLCCKA TIENTVGCAR CTADVKKIDG DRETERIYSL FTINMSKLQK
LEEACGSIAV YQGPRKEPDD YSNFTIEDSV ATFHTLKQII DIVEKLNESH EKYRKKRSSS
AKYGSE
//
