ID A0A087VB28_BALRE Unreviewed; 881 AA.
AC A0A087VB28;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Vacuolar protein sorting-associated protein 11 homolog {ECO:0000256|PIRNR:PIRNR007860};
GN ORFNames=N312_05425 {ECO:0000313|EMBL:KFO09820.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO09820.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO09820.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO09820.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport and
CC autophagic pathways. Believed to act as a core component of the
CC putative HOPS and CORVET endosomal tethering complexes.
CC {ECO:0000256|PIRNR:PIRNR007860}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|PIRNR:PIRNR007860}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007860}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007860}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004630, ECO:0000256|PIRNR:PIRNR007860};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004630,
CC ECO:0000256|PIRNR:PIRNR007860}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004630, ECO:0000256|PIRNR:PIRNR007860}.
CC Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR007860}. Early endosome
CC {ECO:0000256|PIRNR:PIRNR007860}. Cytoplasmic vesicle, autophagosome
CC {ECO:0000256|PIRNR:PIRNR007860}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000256|PIRNR:PIRNR007860}.
CC -!- SIMILARITY: Belongs to the VPS11 family.
CC {ECO:0000256|ARBA:ARBA00007070, ECO:0000256|PIRNR:PIRNR007860}.
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DR EMBL; KL486627; KFO09820.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087VB28; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0033263; C:CORVET complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd16688; RING-H2_Vps11; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR016528; VPS11.
DR InterPro; IPR024763; VPS11_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF24; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF12451; VPS11_C; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR PIRSF; PIRSF007860; VPS11; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|PIRNR:PIRNR007860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR007860};
KW Endosome {ECO:0000256|PIRNR:PIRNR007860};
KW Lysosome {ECO:0000256|PIRNR:PIRNR007860};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR007860};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein transport {ECO:0000256|PIRNR:PIRNR007860};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Transport {ECO:0000256|PIRNR:PIRNR007860};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 762..800
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 712..753
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 881 AA; 101480 MW; C309641E1FCEB087 CRC64;
MEGQIWFLPR SLQLSSFQAY KLRVTHLYQL KQHSILVSVG EDEEGINPLV KVWNLEKRDG
GNPLCTRIFP AIPGNKPTVV SCLTVHENLN FMAIGFADGS VVLTKGDITR DRHSKTQILR
EGSYPVTGLA FRQSGKTTHL FVVTTENIQS YMLSVKDYPH LELDTHGCGL RCSSLSDPSQ
DLQFIVAGNE CVYLYQPDER GPCFAFEGQK LIVHWYRGYL IIVSKDRKTS PKSEFAGNEA
QNSDKQVLNI YDLCNKFIAY SSIFDDIVDV LAEWGSLYVL TRDGKIHVLQ EKDTQTKLEA
RKSMLFRKNL FEMAINLAKS HHLDSDGLSE IFRQYGDHLY NKGNHDGAIQ QYIRTIGKLE
PSYVIRKFLD AQRIHNLTAY LQTLHLQSLA NADHTTLLLN CYTKLKDSSK LEEFIKTSES
EVRFDVETAI KVLRQAGYYS HAVYLAEKHA HHEWYLKIQL EDIKNYQEAL RYIGKLPFDQ
AESNMKRYGK ILMHHVPNET TELLKILCTD YRPLGDSEGP GMLEGKKANS EEFIPVFANN
SRELKAFLEH MTEVQADSPQ GVYDTLLELR LQNWAHEQDE QVKEKLHNEA LTLLKSGRFK
TVFDKALVLC QMHNFKDGVL YLYEQGKLFQ QIMHYHMQNE QYKKVIEVCE LYGDQEACLW
EQALGYFARK EEDCKEYIAA VLKHIENKNL MPPLLVVQTL AHNSTATLSV IKDYLVNKLQ
KQSRQIEQDE QRIQKYREET TRIRQEIEEL KASPKIFQKT KCSICTSALE LPSVHFLCGH
SFHQHCFESY SESDSECPTC MPENRKVMDM IRAQEQKRDL HDQFQHQLKC SNDGFSVVAD
YFGRGVFNKL TLITDLPSGK TATTIEAGLQ RELLMHTKRS T
//
