ID A0A087VDW5_BALRE Unreviewed; 1106 AA.
AC A0A087VDW5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=phosphatidylinositol-4,5-bisphosphate 3-kinase {ECO:0000256|ARBA:ARBA00012010};
DE EC=2.7.1.153 {ECO:0000256|ARBA:ARBA00012010};
GN ORFNames=N312_05194 {ECO:0000313|EMBL:KFO10807.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO10807.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO10807.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO10807.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836,
CC ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153;
CC Evidence={ECO:0000256|ARBA:ARBA00023981};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21293;
CC Evidence={ECO:0000256|ARBA:ARBA00023981};
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004805}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; KL489669; KFO10807.1; -; Genomic_DNA.
DR RefSeq; XP_010300615.1; XM_010302313.1.
DR AlphaFoldDB; A0A087VDW5; -.
DR GeneID; 104635481; -.
DR KEGG; breg:104635481; -.
DR CTD; 5294; -.
DR OrthoDB; 10350at2759; -.
DR UniPathway; UPA00220; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0046934; F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd08399; C2_PI3K_class_I_gamma; 1.
DR CDD; cd00872; PI3Ka_I; 1.
DR CDD; cd00894; PI3Kc_IB_gamma; 1.
DR Gene3D; 3.10.20.770; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR003113; PI3K_ABD.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR000341; PI3K_Ras-bd_dom.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR045580; PIK3CG_ABD.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10048:SF34; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF00794; PI3K_rbd; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19710; PIK3CG_ABD; 1.
DR SMART; SM00142; PI3K_C2; 1.
DR SMART; SM00144; PI3K_rbd; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51544; PI3K_ABD; 1.
DR PROSITE; PS51546; PI3K_RBD; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFO10807.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 34..141
FT /note="PI3K-ABD"
FT /evidence="ECO:0000259|PROSITE:PS51544"
FT DOMAIN 217..309
FT /note="PI3K-RBD"
FT /evidence="ECO:0000259|PROSITE:PS51546"
FT DOMAIN 357..524
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 544..726
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 800..1083
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1106 AA; 128138 MW; 614C66FF1AEA2A9B CRC64;
MELGDYEQPV VMREENKRRR RRMKPHCTSS NLSSMELISI EFILPTSNKH TKVPEMMLLE
IAGNCTVEQM KAQIWMRAIE MSQTADFYHT FTPDQFILQY QKKGQWYEIY DKHQVLQTLD
CILYWKVLQK KVGKIYVVQK QKPSEEVQEF QRQLNNLIGY DVTDVSNVHD DELEFTRRRL
VTPRMIEVAC RDPKLYAMHP WTTSKPLPEY LFKKITNNNI FIIIHRGTTS QKIKVSIDDT
PDMILHSFFT KMAKKKSLMD IPEDHSELDF VLRICGRDEY ITGETPIKDF HWIRQCLKNG
EEIHLVLDNP PDPNEDEVQK EEWPLVDDCT GVTGYHEQLT IDGKDHERVF TISLWDCNRK
FRVKIIGIDI PVLPRNTDLT VFVEANIQHG QQLLSQRRTS SKPFTEEVLW NIWLEFDIKI
KDLPKGALLN LQIYCGKTQG LSTKTNLQSH ESPNSDSKCK TQLLYYVNLL LIDHRFLLRS
GEYVLHMWKI PGKGEEQGSI NADKLTSATN PDKENSMAIS IVLDKYCHPI ALPKHRITSD
PQGDRTRAEM PNQLRKQLEE IIATDPLNPL SPEDKELLWH FRYESIKHPK AYPKLLSSVK
WGQQEIVAKT YQLLAKKEVW DQSTLDVGLT MQLLDCNFSD ENVRAMAVQK LESLEDDDVL
HYLLQLVQAV KFEPYHDSAL ARFLLKRGLR NKRIGHFLFW FLRSEIAQSM HYQQRFAVIL
EAYLRGCGKA MLHDFMKQVQ VIELLHKVTM EIKSVSAEKY DVTSQVIAQL RQKLEKLQSS
KLPESFRVPY DPGLRAGALV IEKCKVMASK KKPLWLEFKC ADPTALSNET IGIIFKHGDD
LRQDMLILQI LRIMESIWEA ESLDLCLLPY GCISTGNKIG MIEIVKDATT IAKIQQSTVG
NTGAFKDEIL NQWLKERCMI EEKFQAAVER FVYSCAGYCV ATFVLGIGDR HNDNIMITET
GNLFHIDFGH ILGNYKSFLG INKERVPFVL TPDFLFVMGT SGKKTSLHFH KFQDVCVKAY
LALRHHTNLL IILFSMMLMT GMPQLTSKED IEYIRDALTV GKSEEDAKKY FLDQIEVCRD
KGWTVQFNWF LHLVLGIKQG VEKHSA
//
