ID A0A087VEY0_BALRE Unreviewed; 635 AA.
AC A0A087VEY0;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Low-density lipoprotein receptor-related protein 2 {ECO:0000313|EMBL:KFO11172.1};
DE Flags: Fragment;
GN ORFNames=N312_08275 {ECO:0000313|EMBL:KFO11172.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO11172.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO11172.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO11172.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KL490769; KFO11172.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087VEY0; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 6.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF12; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4 ISOFORM X1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 6.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00192; LDLa; 6.
DR SMART; SM00135; LY; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 6.
DR PROSITE; PS51120; LDLRB; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:KFO11172.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFO11172.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 358..373
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 511..554
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 1..13
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 65..80
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 85..97
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 92..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 104..119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 122..134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 129..147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 227..242
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 255..267
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 262..280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO11172.1"
FT NON_TER 635
FT /evidence="ECO:0000313|EMBL:KFO11172.1"
SQ SEQUENCE 635 AA; 68993 MW; 0E873BD788C72D8F CRC64;
CAASRQAACS AGCIPVPWLC DGEQQCPDGT DEQARCECCS VPLVCGAKKV QCPGTHHCIP
HWELCDRHQD CEDGWDEEGC PQQPCLPGQW QCRNRVCIMA EWKCNGIDDC GDSSDEDVCA
PCPPGMVRCD EGKCILESLM CNDEDDCLDG TDEPSTCGEL LATARVTGAR GSRRAVLCLV
TPLLFCSARV DIRSGDLYWL AFLRLSCPRT HVPCRDGTEC VAQEYVCDGE KDCADGSDED
GCAQLCDTPG QPAPCQSHEY PCGLGACLNA SLVCDGRQDC ADSSDEGGNC SVPCQRSCAH
LCYPSPQGPP LSPQRCWCDP GYRLAEDGLS CMDIDECMEW GEGACSQTCL NAPGSYSCGC
LPGYLLEPDG RVCKLIGPEP MLLVALQSEV LSYGLRSGHE KVLLATDKDR VVFSLDYDLV
ERKVFWMDLA TESIRWQDLN SGKKGTLVKG VRSDCIAVDW LGRNLYWTDG AAGQVLATHL
GAAWRGIPEY TVVMDGDLDQ PHSLVLQPLA GLLYWSEVGS HPRLMEATMD GSQRHVLLAQ
GLGWPTALAL DLPTWRIFWL DEKLGSIGSA RLDGTSVKVL QLGWVRSPFA AAVGEGQLSW
SEKKAWSVQQ VDKASGKNRT VLLKRHGQPH GLQVP
//
