ID A0A087VFC9_BALRE Unreviewed; 4787 AA.
AC A0A087VFC9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
DE Flags: Fragment;
GN ORFNames=N312_02750 {ECO:0000313|EMBL:KFO11321.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO11321.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO11321.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO11321.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; KL491178; KFO11321.1; -; Genomic_DNA.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd08664; APC10-HERC2; 1.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd14402; UBA_HERC2; 1.
DR CDD; cd02344; ZZ_HERC2; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR021097; CPH_domain.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR037976; HERC2_APC10.
DR InterPro; IPR010606; Mib_Herc2.
DR InterPro; IPR037252; Mib_Herc2_sf.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR InterPro; IPR041987; ZZ_HERC2.
DR PANTHER; PTHR22870; REGULATOR OF CHROMOSOME CONDENSATION; 1.
DR PANTHER; PTHR22870:SF437; X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR-RELATED; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF11515; Cul7; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF06701; MIB_HERC2; 1.
DR Pfam; PF00415; RCC1; 17.
DR Pfam; PF00569; ZZ; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM01337; APC10; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF159034; Mib/herc2 domain-like; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 4.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS51416; MIB_HERC2; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 19.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT REPEAT 453..508
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 509..560
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 563..614
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 615..666
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 667..718
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1147..1223
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT DOMAIN 1800..1873
FT /note="MIB/HERC2"
FT /evidence="ECO:0000259|PROSITE:PS51416"
FT DOMAIN 2646..2698
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 2702..2879
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT REPEAT 2902..2953
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2954..3008
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3009..3060
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3061..3112
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3115..3166
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3167..3218
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3219..3270
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3896..3947
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3948..4001
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4002..4053
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4054..4105
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4108..4159
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4160..4211
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4221..4272
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 4410..4747
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1865..1898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3371..3440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3544..3574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4757..4787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4761..4775
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4715
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO11321.1"
FT NON_TER 4787
FT /evidence="ECO:0000313|EMBL:KFO11321.1"
SQ SEQUENCE 4787 AA; 523183 MW; 1D7400306C350D5B CRC64;
DDSTECQTAS KKEEQNDKEK KDEEETPLPT YRAKSIVESW VWGKQPDVNE LKECLHVLVK
EQQTLATQTA TTALSAMRLK QRLVILERYF IALNRTVLQE NVKVKWKSSS IPLPAVDKKS
PRPVGKGVEG LARVGSRAAL SFAFAFLRRA WRSGEDADLC SELLQESLDA LRALPEASLF
DEGTVSSVWL EVVERATKFL RSVVTGDVHG APSTKGPGNI PLQDQHLALA ILLELAVQRG
TLSQMLSAVM LLLQLWDNGT RETDNERSAQ GTSAPLLPLL QRFQSIICNK DVPNTEEEIQ
LLTYPLSPNE SFLRYLTLPQ DNELAIDLRQ TAVVIMAHLD RLATPCMPPQ CSSPTSHKGS
LQEVIAWGLI GWKYYANVSG PIQCEGLANL GVVQVACAEK RFLILSRNGR VYTQAYNSDT
LGPQLVQSLA SRNIVKIAAH SDGHHYLALS ANGEVFSWGC GDGGRLGHGD TVPLEEPKMI
SALSGKQAGK HVVHIACGST YSAAITAEGE LYTWGRGNYG RLGHGSSEDQ TIPMLVTGLK
GLKVIDVSCG SGDAQTLAVT ENGQVWSWGD GDYGKLGRGG SDGCKTPKLI EKLQDLDIVK
VRCGSQFSIA LTKDGQVYTW GKGDNQRLGH GTEEHVRYPK LLDGLKGKKV IDVAAGSTHC
LALTEDSEVH SWGSNDQCQH FDTLRITKPE PTALPGLDTK HIVGIACGPA QSFAWSSCSE
WSIGLRVPFV VDVCPMTFEQ LDLLLRQVTE GMDGSSDWPP PQEKECMAVA TLNLLRLQLH
AAISHQVDPE CLGLGLGGIL LNSLKQTVVT LASNAGVLNT VQSAAQAVLQ SGWSVLLPTL
GHSQRSCPVQ LLPCLVSGNE MNVSPGRRFM IDLLVGSLMA DGGLESALNA AITAEIQDIE
AKKEAQKEKE IDEQEANAST LHRSRTPLDK DLINTGIYES AGKQSLPLVQ LIQQLLRNIA
SQTIAKLKDV ARRISSCMDH EHCSKERSAS LDLLLRFQRL LVSKLYPGDC VGQVPNTYSP
DLLGVGSLLK KYTALLCTHI GDILPVATSI ASTSHRHFAE VSRVVDGDLT GILLPELVVS
IVLLLSKNAG LMQEAGAIPL LAGLLEHLDR FNHLAPGKDR DDNEDLAWPG IMGSFFTGQS
CRNNEEVTLI RKADLENHNK DGGFWTVIDG KVYDIKDFQT QSLTGGSILA QFAGEDPVVA
LEAALQFEDT RESMHAFCVG QYMEPDQEVI TTPDLSTLSS PLIDTERNLG LLLGLHASYL
AMSTPLSPLE VECAKWLKSS IFSGGLQTSQ IHYSYNEEKD EDHCSSPGNT TPNKSKLYTH
RLTLSDHSQP FLQAIADNNI QDHTVKDFLC QIERYCKQCH LTTPITFPPE HPVEEVGRLL
LCCLLKHEDL GHVALSLVHP GALGVDQVKH KTLPKSVVDV CRVVYQAKCS LIKTHQEQGR
SYKEVCAPVI ERLRFLFNEL RPAVCNDLSI MSKFKLLSSL PRWRRVAQKI IREKRKKRVP
KKSESADVEE SKIGNEESDL EESCVVPHSP VPIDKRPIPI KSPKDKWQPL LSTVTGVHKY
KWLKQNVQGL YPQSALLNTI VEFALKEEPV DVEKMRKCLL KQLERAEVRL EGIDTILKLA
AKNFLLPSVQ YAMFCGWQRL IPEGANIGEP LTDCLKDVDL IPPFNRMLLE VTFGKLYAWA
IQNVRNILLD ANAKFKELGV QPVPLQTITN ENPAGPSLGT IPQARFLLVM LNMLTLQHGA
NTLSLLLNSG MLALTQTTLR LIGPSSDNIE EDMIASSRGA SATVLEESRK ETTPVQLPVS
GPELAAMMKI GTRVVRGVDW KWGDQDGPPP GLGRVIGELG EDGWIRVQWD TGSTNSYRMG
KEGKYDLKLA EPPPATQPTT EDSDTEDDSE GEQVERNLHP TSMMLTSTVN LLQTLCLSAG
VHAEVMQSDA TRTLCGLLRM LVESGTIDKS ASLPNKLVYK EQHRSWCTLG FIRSIALMPQ
MCSTLSTSQW ITLLMKIVEG HESFTAASLQ RQILAVHLLK AVLPSWDKNE RSRDMKFLVE
KLFGFLGSLL STCSSDIPLL RESTLRRRKA RPQASLTATH SSTLAEEIVA LLRTLHSLSQ
WNGLINKYIN SQLTSITHIF AGKQSEGALL DDYFPDTENP EVGGLMAVLA VIGGIDSRLR
LGGQVVHDEF GEGTVTRITP KGKITVQFYD MRTCRVCPLN QLKPLPVVAF NVNNLPFTEP
MLSIWAQLVN LAGSKIEKQR MKSPNQGLSG QVDLDLLRCQ QLKLYILKAG RALLSHQDTL
RQILSQPAVQ ECALNPAEDG AVASPDIGDM SPEGPQPPMI LLQQLLTAAT QPSPVKAIFD
KQELEAAALA VCQYLAVEST HPSTPVFEDC SSSEATTPIT VQHIRPTKMK KRKQSPIPPL
PIVVQLMEMG FPRKNIEFAL KSLSGTSGSA SGLPGVEALV GWLLDHPDVQ ITDLSDADTI
SDEYSDEEIT EEVEEAEAAC PVSSGAVVTE SQTYKKRADF LSNDDYAVYV RENIQVGMMV
RCCRTYEEVC EGDVGKVIKL DRDGLHDLNV QCDWQQKGGT YWVRYIHVEL LGFPPQSSAS
HIKIGDKVRV KSSVTTPKYK WGSVTHRSVG VVKAFSANGK DVIVDFPQQS HWTGLLSEME
LVPSIHPGVT CDGCQMFPIN GPRFKCRNCD DFDFCETCFK TRKHNTRHTF GRINEPGQSP
VFCGRSGKQL KRRHSSQRGM LLDDWSRIVK NLNVSSSVNQ ASRLIDGSEQ CWQSSGSQGK
HWIRLEIFPD VLVHRLKMIV DPADSSYMPS LVVVSGGNSL NNLIELKTIN INPTDTTVPL
LSDCTEYHRY IEIAIKQCRS SGIDCKIHGL SILGRIRAED EDLAAVPFLA SDNEEEDDDK
ANTGSLVRKK AAGLESAATI RTKVFVWGLN DKDQLGGLKG SKIKVPSFSE TLSALNVVQV
AGGSKSLFAV TVEGKVYACG EATNGRLGLG ISSGTVPIPR QITALSNYVV KKVAVHSGGR
HAMALTVDGK VFSWGEGDDG KLGHFSRMNC DKPRLIEALK TKRIRDIACG SSHSAAITSS
GELYTWGLGE YGRLGHGDNT TQLKPKMVKV LLGHRVIQVA CGSRDAQTLA LTDEGLVFSW
GDGDFGKLGR GGSEGCNIPQ NIERLNGQGV CQIECGAQFS LALTKSGVVW TWGKGDYFRL
GHGTDVHVRK PQVVEGLRGK KIVHVAVGAL HCLAVTDTGQ VYAWGDNDHG QQGNGTTTVN
RKPTLVQGLE GQKITRVACG SSHSVAWTTV DVATPSVHEP VLFQTARDPL GASYLGVPSD
ADSSAASNKI SGANSSKPNR PSLAKILLSL DGNVAKQQAL SHILMALQIM YARDAVVGAL
MPASMIAPVE CPSSSPAPPS DVTSAGSPAN GDECVLVGDV EERLSPNPWQ DRRGEVASSE
DAVTPSAVTP SAAAASSRPF IPVTDDPGAA SIIAETMTKT KEDVESQSKV SGPEPQYLDE
FTSLLVPDDT RVMVDLLKLA VSNRAGEKGR DVLSAVLSGM GTAYPQVADM LLELCVTELE
DVATDSQSGR LSSQPVVVES SHPYTDDTSS SGTVKIPGAE GLRVEFDRQC STERRHDPLT
IMDGVNRIVS VRSGREWSDW SSELRIPGDE LKWKFISDGS VNGWGWRFTV YPIMPAAGPK
DLLSDRCILS CPSMDLVTCL LDFRLNFASN RSIVPRLAAS LAACAQLSAL AAGHRMWALQ
RLRKLLTTEF GQSININRIL GDNDGETRAL SFTGSALAAL VKGLPEALQR QFDYEDPIVR
GGKQLLHSPF FKVLVALACD LELDTLPCCA ETHKWAWFRR YCMASRVAVA LDKRTPLPRL
FLDEVAKKIR ELMADNENMD VLHECHDLFK REQDEQLVQW MNRRPDDWTL SAGGSGTIYG
WGHNHRGQLG GIEGAKVKVP TPCEALATLR PVQLIGGEQT LFAVTADGKL YATGYGAGGR
LGIGGTESVS TPTLLESIQH VFIKKVAVNS GGKHCLALSS EGEVYSWGEA EDGKLGHGNR
SPCDRPRVIE SLRGIEVVDI AAGGAHSACI TAAGDLFTWG KGRYGRLGHG DSEDQLKPKL
VEALQGYRVI DIACGSGDAQ TLCLTDDDTV WSWGDGDYGK LGRGGSDGCK VPMKIDSLTG
LGVVKVECGS QFSVALTKSG AVYTWGKGDY HRLGHGSDDH VRRPRQVQGL QGKKVIAIAT
GSLHCVCCTE DEQLIIFIGL GEVYTWGDND EGQLGDGTTN AIQRPRLVAA LQGKKINRVA
CGSAHTLAWS TSKPANAGKL PTQVPMEYNH LQEIPIISLR NRLLLLHHIS ELFCPCIPMF
DLEGRLDETG QGPSVGFDTL RGILISQGKE AAFRKVVQAT MVRDRQHGPV VELNRIQVKR
SRSKGGLAGP DGTKSVFGQM CAKMSSFSPD SLLLPHRVWK VKFVGESVDD CGGGYSESIA
EMCEELQNGL TPLLIVTPNG RDESGANRDC FLLNPAAKSL LHMNMFRFLG VLLGIAIRTG
SPLSLNLAEP VWKQLAGMNL TIADLSEVDK DFIPGLMYIR DNEATSEEFE AMSLPFTVPN
ASGQDIQLSS KYTHITLDNR AEYVRLAINY RLHEFDEQVA AVREGMARVV PVPLLSLFTG
YELETMVCGS PDIPLHLLKS VATYKGIEPT ASLIQWFWEV MESFSNTERS LFLRFVWGRT
RLPRTIADFR GRDFVIQVLD KYNPPDHFLP ESYTCFFLLK LPRYSCKQVL EEKLKYAIHF
CKSIDTDDYA RIALTGEPAA DDSSDDSDNE DADSFASDST QDYLTGH
//
