ID   A0A087VIG6_BALRE        Unreviewed;       813 AA.
AC   A0A087VIG6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Two pore calcium channel protein 1 {ECO:0000313|EMBL:KFO12408.1};
GN   ORFNames=N312_03920 {ECO:0000313|EMBL:KFO12408.1};
OS   Balearica regulorum gibbericeps (East African grey crowned-crane).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX   NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO12408.1, ECO:0000313|Proteomes:UP000053309};
RN   [1] {ECO:0000313|EMBL:KFO12408.1, ECO:0000313|Proteomes:UP000053309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO12408.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KL494620; KFO12408.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A087VIG6; -.
DR   Proteomes; UP000053309; Unassembled WGS sequence.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 2.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1_animal.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR46474; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR   PANTHER; PTHR46474:SF1; TWO PORE CHANNEL PROTEIN 1; 1.
DR   Pfam; PF00520; Ion_trans; 2.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        103..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        169..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        225..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        294..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        441..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        473..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        503..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        566..590
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        662..687
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          107..326
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          437..687
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          9..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          776..813
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        787..813
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   813 AA;  94452 MW;  73EE6BC79F4B4F33 CRC64;
     MDDDVPLILT LDDSGSSTSA PLDDLDREEL PNENGGTYDV VNDASSPAAG DCCAQQSSAQ
     HNWEMNYQEA AIYLQEGENN DKFFTHPKNA KALAAYLFAH NHLFYLMELS TALLLLLLSL
     CEAPAVPMLR LGIFVHATLE LFALIVVVFE LSMKMRWLGF QTFIRHKRTM VKTCVLFVQF
     IEAIVVLVRQ TSHVRITRAL RCIFLVDCRY CGAVRRNLRQ IFQSLPPFID ILLLLLFFMV
     IFAILGFYLF SPNHSDPYFN TLENSLVNLF VLLTTSNFPD VMMPSYARNP WSCVFFIVYL
     SIELYFIMNL LLAVVFDTFN DIEKRKFKSL LLHKRTAIQH AYRLLITKQR PSGISFKHFE
     GLLRFYKPRM CARERYLTFK ALNQSNTPLV SLKDFYNFYE VVGLKWKAKR NREHWFDDLP
     RTAFLIFKGI NILVNSRVFQ YTMYTVVAVN GIWILVETFM LQGGNFFSRN VPWSYIVFLT
     IYGVELLLKT TGLGPVEYLS SGWNLFDFSV TLFAFLGLMA LAFNMEPFYF IVVLRPLQLL
     RLFKLKKRYR NVLDTMFELF PRMASLGLTL LIFYYCFAIV GMEFFAGVVY PNCCNTSTVA
     DSYRWVNHTV GNKTVVEEGY YYLNNFDNIL NSFVTLFELT VVNDWYIIME GVTSQTTHWS
     RLYFMIFYIV TMVVMTIIVA FILDAFVFRM NYTRKNQDSE EDNGIVLEKE ISKEEVVGII
     ELYKRSSAAA ETAQLQKMVL QMDKYGQMST LFLGRRSRTK SDLSMKMYEE EIQEWYEEHS
     RKEESQTPLQ EPVSASNSSL KPLSLRQRSQ TVI
//