ID A0A087VIH8_BALRE Unreviewed; 2804 AA.
AC A0A087VIH8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Fibrillin-1 {ECO:0000313|EMBL:KFO12420.1};
DE Flags: Fragment;
GN ORFNames=N312_04036 {ECO:0000313|EMBL:KFO12420.1};
OS Balearica regulorum gibbericeps (East African grey crowned-crane).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Balearica.
OX NCBI_TaxID=100784 {ECO:0000313|EMBL:KFO12420.1, ECO:0000313|Proteomes:UP000053309};
RN [1] {ECO:0000313|EMBL:KFO12420.1, ECO:0000313|Proteomes:UP000053309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N312 {ECO:0000313|EMBL:KFO12420.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KL494645; KFO12420.1; -; Genomic_DNA.
DR Proteomes; UP000053309; Unassembled WGS sequence.
DR GO; GO:0001527; C:microfibril; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 27.
DR Gene3D; 2.10.25.10; Laminin; 46.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 3.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 37.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 47.
DR SMART; SM00179; EGF_CA; 44.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 10.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 41.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 25.
DR PROSITE; PS50026; EGF_3; 41.
DR PROSITE; PS01187; EGF_CA; 17.
DR PROSITE; PS51364; TB; 9.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000053309};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 91..123
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 129..172
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 191..232
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 233..274
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 279..334
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 387..425
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 428..467
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 468..509
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 510..550
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 551..591
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 597..649
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 661..702
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 703..744
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 745..780
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 789..828
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 848..889
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 894..945
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 965..1006
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1007..1049
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1050..1091
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1092..1133
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1134..1174
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1175..1216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1217..1254
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1259..1299
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1300..1338
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1341..1382
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1383..1419
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1424..1464
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1469..1526
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1543..1584
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1585..1621
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1630..1685
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1703..1744
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1745..1785
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1786..1823
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1826..1861
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1865..1907
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1908..1947
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1948..1989
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1994..2046
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2062..2098
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2101..2140
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2226..2263
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2272..2325
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2337..2378
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2420..2456
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2459..2501
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2502..2534
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2540..2576
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 2660..2681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 95..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 113..122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 432..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 749..759
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1830..1840
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2506..2516
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO12420.1"
FT NON_TER 2804
FT /evidence="ECO:0000313|EMBL:KFO12420.1"
SQ SEQUENCE 2804 AA; 305086 MW; 6608F73781DB4B3C CRC64;
PNVCGSRYNA YCCPGWKTLP GGNQCIVPIC RHSCGDGFCS RPNMCTCPNG QIAPSCGSKS
IQHCNIRCMN GGSCSDDHCL CQKGYTGTHC GQPVCENGCL NGGRCVAPNR CACTYGFTGP
QCERDYRTGP CFTLITNQMC QGQLSGIVCT KTLCCATVGR AWGHPCEMCP AQPHPCRRGF
IPNIRTGACQ DVDECQAIPG ICQGGNCINT VGSFECKCPA GHKFNEVTQK CDDIDECSTI
PGICDGGECS NTVSSYFCKC PPGFYTAPDG LKCIDVRPGY CFSSLTNGRC GNQLPQPLSK
MQCCCDSGRC WSSGAATAPE MCPIRSTDEY RKLCTVAALL PARPDLPPGR PDVIPPPLLP
GVFPPQQPEI VYPSRAPPPH VILPVNFTDY CQLFRHLCLN GRCIPTPGSY RCECNKGFQL
DVRGECIDVD ECEKNPCISG DCVNTQGSYI CQCRIGYQST PTRTECRDID ECLQNGRICN
NGRCINTDGS FHCVCNAGFQ VAADGKNCED MDECSIRNMC LNGMCINEDG SFKCICKPGF
QLASDGRYCR DIDECETAGI CMNGRCVNTD GSFRCECFPG LAVGLDGRVC VDTHMRSTCY
GGYKRGQCVR PLTGAVTKSE CCCASTDYAF GEPCQPCPAQ NSAEYQALCS SGTGMTAGGN
DINECLLDTD LCPNGRCENL HGTYKCICNP GYEVDSTGKN CIDIDECALN MLLCDNGQCR
NTPGSFTCTC PKGFVYTPDL KTCEDIDECE SNPCVNGVCK NTPGSFACEC SPESTLDTTR
TICIETVKGT CWQNIVDGRC EININGATLK SQCCSSLGAA WGSPCTPCER DPICQKGYSR
IRGTLCEDVN ECEVFPGVCT NGQCVNTLGS FVCQCPNGMS LDASGRTCLD IRLESCYLQH
EDEQCTSQIP GRHRMDACCC SVGAAWGFEC EECPLKGSPE FEALCPRGSG FSTKIEITGK
PFSKDINECK MVPSLCTHGR CRNTIGSFKC RCDSGFALDS EERNCTDIDE CRISPDLCGQ
GICVNTPGDF ECECFEGYES GFMMMKNCMD IDECQRNPLL CRGGTCINTE GSFRCDCPPG
HQISPNISAC IDINECDLST SLCRNGHCVN LIGKYQCACN PGYQSTADKL YCVDIDECSI
MNGGCENFCT NSEGSYECSC KQGFALMPDH RTCTDIDECE DNPNICDGGQ CTNIPGEYRC
LCYDGFMASE DMKTCIDVNE CDLHPNICLS GTCENTKGSF ICHCDMGYSG KKGTTGCTDI
NECEIGAHNC DRHAICTNTA GSFKCSCSSG WIGNGIKCTD LDECSNGTHM CSPHADCKNT
MGSYRCLCKE GYTGDGFTCT DLDECSENLN LCENGQCLNA PGGYRCECDM GFLPSPDGKA
CEDIDECSLP NICVYGTCHN LPGLFRCECE VGYELDRSGG NCTDVNECAD PTTCISGTCV
NTAGSYTCEC PPDFELNPTR VGCVDTRSGN CYLDIKTRGD NGGTFCSNEI GVGVSKASCC
CSLGKAWGVP CEHCPLVNTT EYKVLCPGGE GFRPNPITVI LEDIDECQEL PGLCQGGKCI
NTFGSFQCQC PSGYYLNEET RVCDDVNECD TPGICGPGTC YNTVGNYTCI CPPDYMQVNG
GNNCMDMRRS LCYRNYYADN QTCDGELLFN MTKKMCCCSY NIGRAWNKPC EQCPIPSTDE
FSTLCGSQRP GFFIDIYTGL PVDIDECREI PGVCENGICI NMVGSFRCEC PVGFFYNDKL
LICEDIDECQ NGPVCQQNAE CVNTAGSYRC DCKPGYRFTS TGRCTDRNEC QEIPNICSHG
QCIDTVGSFY CICHNGFKTN DDRTMYINEC ERDACGNGTC RNTIGSFNCR CNLGFILSHN
NDCIDVDECA SGNGMLCRNG QCVNTIGSFQ CLCNDGYEVA LDGRTCVDVN ECALEPGKCS
PGTCQNLDGS FRCICPPGYV LQNDKCEDID ECVEQPEICA LGTCSNTPGS FKCLCPEGFV
LSSTGRRCQD LRVSYCFTKF EDGKCSVPKS RNHSKQECCC ALKGQGWGDP CELCPEEADE
AFRQICPFGI GILVGPGDAR LDVDECLDPD NCKFGQCINT DGSFRCECPY GYILQGAQCV
DTDECAVGNP CGNGTCRNVV GGFECTCVEG FEPGPMMTCE DVNECIQNPL LCAFRCVNTF
GSYECKCPAG YVLREDRRMC RDQNECEEGI HDCDSKQMEC KNLIGTYMCI CGPGYQRRPD
GEGCIDENEC QTKPGICENG RCVNTVGSYR CECNEGFTVS DTQNECLDNR EGYCFTEVLQ
SMCQIGSSNR NSVTKSECCC DGGRGWGQNC EVCPFPGTVA FKKLCPHGRG YMSNGADIDE
CKVIHDVCRN GECINERGSY RCHCNLGYTT DITGTLCIDL NECNESPKPC NFICKNTEGS
FQCSCPKGYI LQEDGRSCKD LDECATKQHN CQFLCVNTIG GFTCKCPPGF TQHHTACIDN
NECATEINLC GAKGICQNTP GSFVCECQRG FSLDQTGLSC EDVDECDGNH RCQHGCQNII
GGYRCSCPQG YLQHYQWNQY ENECLSAHIC GGASCHNTLG SYKCMCPTGF QYEQFSGGCQ
DINECGSAQA PCSYGCSNTE GGYVCGCPPG YFRIGQGHCV SGVGLGKGQG QELSLSGEVD
DNSLSPEACY ECKINGYPKR GRKRRSTNET ANEAEDQQEL EPPISLASWD IEKAAVFSIN
ISDLSNKDRI LELLPALTTL TNHNRYLIDS GNEDGFFRIN KKDGISYLHF TKKKPVPGNY
SLQISSIPLY KKKELNQLEE KHDKDYLSGE LGDNLKMKIQ ILLH
//
