ID A0A087VZJ5_ECHMU Unreviewed; 1635 AA.
AC A0A087VZJ5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN ORFNames=EmuJ_000140800 {ECO:0000313|EMBL:CDI97618.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDI97618.1};
RN [1] {ECO:0000313|EMBL:CDI97618.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDI97618.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; LN902844; CDI97618.1; -; Genomic_DNA.
DR STRING; 6211.A0A087VZJ5; -.
DR eggNOG; KOG2301; Eukaryota.
DR OMA; FRIFCHN; -.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF1; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 755..777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 823..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..958
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 999..1023
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1043..1062
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1094
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1139..1159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1233..1257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1397..1431
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 606..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1453..1475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1458..1473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 212
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 553
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 904
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1635 AA; 186293 MW; 282A1AE6895876E6 CRC64;
MGDYNATNVA LEKTELVFLI IFTTEAVLKI IAYGFVLHPD AYLRNFWNVL DFSIVVIGLG
SKCLENTKLD VKSLRAFRVL RPLRLVSGLP SLQVVLNSIV TAMVPLFHIF LLVIFLIIIY
AIIGLELFQS KLHATCYLVQ ENTTYTMMDN PRPCSNSSYS MAFNCSEIGP NYVCRDLPPE
LGERYVGPED GLVNFDNFLY AMLTVFTCVT MEGWTTFGAY IAAAVGHWWP WIYFVSLILL
GSFFVMNLVL GVLSGEFTKE KDKTDRKELF RKERQQRREQ QDYENYKEWI EIAGLMDGKS
VEDQEAANEP TAKSQCCEGM RRLKKFRKRL RRVITAFVKS RQFFALILTF VFLNTIVLVT
EHHNQPLWLN QFQSKSICTY RLIRTSFPQN RGFQSYICIL SHEDFANVLF VSLFTLEMII
KMCAYGIQDY FATLFNRYDF FVVVVSILEI ILTYIGVIDP MGLSVLRCAR LLRIFKITHY
WAGLRGLVNR LLKSIKSVAG LLLLLFLFIL ICSLLGMQWF GGTFNFPNTD KPRSHFDGIA
QSMITVFQML TGEDWNAVMY NGMRAYKADG PLFAFVVIYF VIVFVVGNYI LLNVFLAIAV
DNLSDEDEDD EEGGMDDDND VDDHPGSSAA AKKAAEAAVN AKGPLDAYME MNYEEVFAEE
EEPDDGNLAS KLEQMEINMA NPQTIPPYSA FFIFDPTNKF RIFCHNIVSS PIFTNLVLAC
ILISSALLCA EDPLNTYSLT NRMIAHGFIM HEGAFLRSMF NLLDLIVVFV ALISFMLENE
AISAVKILRV LRVLRPLRAI NRAKGLKNVV QCVVTALKSI GNIMLVTVLI EFVFAVIGVQ
LFKGKYVSCN DPSKLTEQDC KGFFIEYEHG RPADVVERVW THSELNFDNV ANAMLTLFVV
LTFEGWPPIL YAGIDSNEED MGPLQDHRKY IALYFIIYLI VASFFMVNIF VGFVIVTFQR
EGEREYKNCE LNKNQRKCIE YALKARPRRR YIPKGHLQYK IWSMVVSRKM EITIFTFIFL
NTVTLACKHD KMDPTFSSVL DNFNYFFTAV FTVEFILKLS AFSFRHYFGD PWNVIDFIIV
LGSYIDIIVS KASSETTLKF NINFFRLFRV MRLVKLLSKE ESIRKLLWTF IKSLQALPYV
ALLIAMLFFI YAVIGMQLFG KISLHQPGLA LGEDGVIHRS NNFRNFFFAL LVLFRSATGE
SWQEIMLACT PGRKCAVDSE DGSEGMNCGS NLAYPYFITF YLFCSFVIIN LFVAVIMDNF
DYLTRDWSIL GPHHLDEFVT RWAEYDPEAK GRVRHLDVVT MLGKISPPLG FGSMCPHTRA
CHKLVQMNMP LQSDGTVFFN ATLFALVRRN LRIKVPEDDE KEKSLDQLNE ELRIVIKKIW
KRTSPKLLDQ ILPPKELDVV TVGKFYATFL IQNWFREWQK RKMIQKDTRY IPQILAGDRS
MPHQPTIVGF PRRCSSDLTG DDIQRRKGEK RDVIPGGGIL GRTLTDWTRK RGKKHISSGH
RDITEDVSEL RKRQLQAGGI VGGAGASVGG GGPNGLPQPG GQMPAIQVTA AHPAVIAVAT
LGDKKIKTTI PAPSAEEKGG GGIMGLIRRG SSYLRRKEAE EQQQRQEEER KEDLEIARSM
FAAARRESYY AHRAD
//