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Database: UniProt
Entry: A0A087VZJ5_ECHMU
LinkDB: A0A087VZJ5_ECHMU
Original site: A0A087VZJ5_ECHMU 
ID   A0A087VZJ5_ECHMU        Unreviewed;      1635 AA.
AC   A0A087VZJ5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=EmuJ_000140800 {ECO:0000313|EMBL:CDI97618.1};
OS   Echinococcus multilocularis (Fox tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX   NCBI_TaxID=6211 {ECO:0000313|EMBL:CDI97618.1};
RN   [1] {ECO:0000313|EMBL:CDI97618.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23485966; DOI=10.1038/nature12031;
RA   Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA   Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA   Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA   De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA   Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA   Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA   Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA   Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA   Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA   Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA   Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA   Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA   Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT   "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL   Nature 496:57-63(2013).
RN   [2] {ECO:0000313|EMBL:CDI97618.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhang Y., Guo Z.;
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC       of calcium ions into excitable cells and are also involved in a variety
CC       of calcium-dependent processes, including muscle contraction, hormone
CC       or neurotransmitter release, gene expression, cell motility, cell
CC       division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC       1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; LN902844; CDI97618.1; -; Genomic_DNA.
DR   STRING; 6211.A0A087VZJ5; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   OMA; FRIFCHN; -.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 4.
DR   Gene3D; 6.10.250.2180; -; 1.
DR   Gene3D; 6.10.250.2500; -; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR   PANTHER; PTHR45628:SF1; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW   ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW   ECO:0000256|RuleBase:RU003808};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR602077-1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        106..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        198..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        405..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        439..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        470..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        500..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        572..600
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        712..734
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        755..777
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        823..842
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        931..958
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        999..1023
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1043..1062
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1074..1094
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1139..1159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1233..1257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1397..1431
FT                   /note="Voltage-dependent calcium channel alpha-1 subunit
FT                   IQ"
FT                   /evidence="ECO:0000259|SMART:SM01062"
FT   REGION          606..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1453..1475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1458..1473
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         212
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT   BINDING         553
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT   BINDING         904
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ   SEQUENCE   1635 AA;  186293 MW;  282A1AE6895876E6 CRC64;
     MGDYNATNVA LEKTELVFLI IFTTEAVLKI IAYGFVLHPD AYLRNFWNVL DFSIVVIGLG
     SKCLENTKLD VKSLRAFRVL RPLRLVSGLP SLQVVLNSIV TAMVPLFHIF LLVIFLIIIY
     AIIGLELFQS KLHATCYLVQ ENTTYTMMDN PRPCSNSSYS MAFNCSEIGP NYVCRDLPPE
     LGERYVGPED GLVNFDNFLY AMLTVFTCVT MEGWTTFGAY IAAAVGHWWP WIYFVSLILL
     GSFFVMNLVL GVLSGEFTKE KDKTDRKELF RKERQQRREQ QDYENYKEWI EIAGLMDGKS
     VEDQEAANEP TAKSQCCEGM RRLKKFRKRL RRVITAFVKS RQFFALILTF VFLNTIVLVT
     EHHNQPLWLN QFQSKSICTY RLIRTSFPQN RGFQSYICIL SHEDFANVLF VSLFTLEMII
     KMCAYGIQDY FATLFNRYDF FVVVVSILEI ILTYIGVIDP MGLSVLRCAR LLRIFKITHY
     WAGLRGLVNR LLKSIKSVAG LLLLLFLFIL ICSLLGMQWF GGTFNFPNTD KPRSHFDGIA
     QSMITVFQML TGEDWNAVMY NGMRAYKADG PLFAFVVIYF VIVFVVGNYI LLNVFLAIAV
     DNLSDEDEDD EEGGMDDDND VDDHPGSSAA AKKAAEAAVN AKGPLDAYME MNYEEVFAEE
     EEPDDGNLAS KLEQMEINMA NPQTIPPYSA FFIFDPTNKF RIFCHNIVSS PIFTNLVLAC
     ILISSALLCA EDPLNTYSLT NRMIAHGFIM HEGAFLRSMF NLLDLIVVFV ALISFMLENE
     AISAVKILRV LRVLRPLRAI NRAKGLKNVV QCVVTALKSI GNIMLVTVLI EFVFAVIGVQ
     LFKGKYVSCN DPSKLTEQDC KGFFIEYEHG RPADVVERVW THSELNFDNV ANAMLTLFVV
     LTFEGWPPIL YAGIDSNEED MGPLQDHRKY IALYFIIYLI VASFFMVNIF VGFVIVTFQR
     EGEREYKNCE LNKNQRKCIE YALKARPRRR YIPKGHLQYK IWSMVVSRKM EITIFTFIFL
     NTVTLACKHD KMDPTFSSVL DNFNYFFTAV FTVEFILKLS AFSFRHYFGD PWNVIDFIIV
     LGSYIDIIVS KASSETTLKF NINFFRLFRV MRLVKLLSKE ESIRKLLWTF IKSLQALPYV
     ALLIAMLFFI YAVIGMQLFG KISLHQPGLA LGEDGVIHRS NNFRNFFFAL LVLFRSATGE
     SWQEIMLACT PGRKCAVDSE DGSEGMNCGS NLAYPYFITF YLFCSFVIIN LFVAVIMDNF
     DYLTRDWSIL GPHHLDEFVT RWAEYDPEAK GRVRHLDVVT MLGKISPPLG FGSMCPHTRA
     CHKLVQMNMP LQSDGTVFFN ATLFALVRRN LRIKVPEDDE KEKSLDQLNE ELRIVIKKIW
     KRTSPKLLDQ ILPPKELDVV TVGKFYATFL IQNWFREWQK RKMIQKDTRY IPQILAGDRS
     MPHQPTIVGF PRRCSSDLTG DDIQRRKGEK RDVIPGGGIL GRTLTDWTRK RGKKHISSGH
     RDITEDVSEL RKRQLQAGGI VGGAGASVGG GGPNGLPQPG GQMPAIQVTA AHPAVIAVAT
     LGDKKIKTTI PAPSAEEKGG GGIMGLIRRG SSYLRRKEAE EQQQRQEEER KEDLEIARSM
     FAAARRESYY AHRAD
//
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