ID A0A087W0H9_ECHMU Unreviewed; 1667 AA.
AC A0A087W0H9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=EmuJ_000186500 {ECO:0000313|EMBL:CDI98041.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDI98041.1};
RN [1] {ECO:0000313|EMBL:CDI98041.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDI98041.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902846; CDI98041.1; -; Genomic_DNA.
DR STRING; 6211.A0A087W0H9; -.
DR eggNOG; KOG4228; Eukaryota.
DR OMA; CYIRRVL; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00047; PTPc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF449; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:CDI98041.1}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..42
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 43..1667
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001831691"
FT TRANSMEM 1197..1218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1285..1652
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1517..1643
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1667 AA; 188058 MW; 23B02D462336D9E2 CRC64;
MRRCVSESDI VFHRCSHTTH IRQMRLHLFL LCLLTGLSAV NAAEAERCFD AWIFTDHPVA
ISIKPSFKKH ASTIGQQRER DVQWIFELLN RADSVQMQPI RDYWGRQVQV DCVAEKKFYN
GTAKMSIRID KVNLKMEQCP FVTWQARSES PTRCRIFRTS ASDVPLNFIV FNRTAQMQAQ
LGARQTSFCL DRLSPATTYL LCLASHECQN DWNCEAFTTL QATSQDMPPY AMDVYAEWTD
SKWVQLSWPP PKIRRPASPP IGYVISVRRD ENCWEREVLL SAPWATEMER AHIRKSAERL
EWAHRCGGRT ARVVDGQLDG YWPDFAGSRL QTWVEGWNGA DVDEQGPLGI FAVTVGDLQA
NTFYKFAITP IFHPHSNILS RSTDIQIKTA SYDSRVSVEA GGGSMWISYP RAYDLTISEI
GAYPIHCNHS SPTFNNGAAE ILCRKSFHST RQKVKISLIP GAVYRLKMDS SYSEPLLQKV
VRIPPERPKF QPQIKAIALS SNLVFINVIH LNATVSNPLA FITRICQTTD TRQCKLHPLH
YEVVSSYSLY QNRSVWRLSN FGDSAHFNAR IQTTNRANLQ VSLYAYPGDP HTGEEVQLAT
TTSEPRKDAC KSWCVWPVSD WSNTNGGAVG AYNREFARRT SDGDVCEGYC EPLSEAIDGE
SGCTPLHKRM QLCNLPVCSA VAPIGCVTDA DSAQGTSWIS VEWKNPRESV GSFPKFLILV
TSHYDAEVGQ VFVENTDTTL LPPFLQSAVQ SLHRPQVHLI TDGVDRVNIT NLAQNMDYNI
AVIPYLLDGR IGAVLEKTAK TKMAAPCRIA YVKIRRNGSH VSVTWQLQLE RTCSVPTDLV
VEINETRRDV KLEHPFDRAH LTHNFEFCRT YHFRLRFDSF GGRREYPHAL SSEIGYPDIA
DTAPFTYLSN TAPYFGVSFT PKHSSCVYEY ALQWGIWPNF QHCKVIAASP TGSNLPTLKE
GFVYNFKARV QPPGLTPNCN NETFASAWSE PLTIATALSK SEVKTHNVTV TAYIVEREEK
EESSSACPLP QAEYSEHHEL REVDNSISRS GDNASVCIIV DWTVDATSAG SILGYILQLT
QSAANNCRLI WVPCEDCFPG YGLRNASPEV AQQLRRIASQ CIEDSTQLLQ NAEQVNSKLY
KTTMRLVLGF ESLGEANDTL TGTVRVHAVK MGSIHQIMVQ FWQTNAQVIL SKGRFRAGLI
TGILAIVLIT ILIAIVIIRK RRAKIIRQDQ YMKVANEDED ALEADSMNIV QKKFGSRLRK
APPPIHLSHF VNTVANYATN DYAILREEFK TLQCNAAIQQ DEKGLTMEVG AHPENQLRNR
YKNVLPFDHN RLKLTKKYAL ADLCTMDESD PKATPLALNA LSDYVNASLI PSTPPLLSIN
CATAKPECRS CPNVYVAAQA PKRCSVALFW QAIWDSNVRV IVMLTRLHER EKEKCWPYWP
RKHDNRDGDG EGDGLNSELC SATYGNFAVT LQSTETGFCY IRRVLVIHNK AVENTIPRRV
IQLLMTSWDD FKVPRKDDFY IFLKKYWDDL KAMNRQSVGS VLVHCSAGVG RTGTFIAIDM
LARYIEGLVE LGKRRVSSKT KAGDNSVTWQ ESIYANLTES GKAILLHNRA TLDKSTSTVD
IFQTVLWIRS QRLKSVQQDI QYIFIHDFLS YYIQSLTGEV EFPIDSV
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