ID A0A087W101_ECHMU Unreviewed; 1036 AA.
AC A0A087W101;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=SH2 motif {ECO:0000313|EMBL:CDI98363.1};
GN ORFNames=EmuJ_000221000 {ECO:0000313|EMBL:CDI98363.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDI98363.1};
RN [1] {ECO:0000313|EMBL:CDI98363.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDI98363.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902844; CDI98363.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087W101; -.
DR STRING; 6211.A0A087W101; -.
DR eggNOG; ENOG502SB92; Eukaryota.
DR OMA; HMISHYE; -.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR15127; HEAVYWEIGHT, ISOFORM A; 1.
DR PANTHER; PTHR15127:SF32; HEAVYWEIGHT, ISOFORM A; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 942..1036
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1036 AA; 110633 MW; B72D377BABD97733 CRC64;
MMALGHGSSS KKHRKSRREG NSTEESPKPI KSLMQVFWRR HSSSSSNNPE KVATSPRTRT
LSPSQSPLSR KTSAPAVSSL EQALRIARGQ VEDEVGEIRE KGESAAYDLT SEALAYQSPP
PGRFLPRIPE HGEGNYSATQ MEQLKASVVR RPNSRSDRSS FNSAPPGTYW PDGGTTPQPV
ISHQPQQQPQ PQHHSPAFGL VERLPRIPPL SRPTSSVFFG GARSPVTSFC ASPARTVSPT
PFFHRPLPPP PPLVDRRGDK MSKSFNLGGS SGPMWHAIPP KSPAGEIEVI DTAVYSNVKI
PLLRMASPPA GSGSSTGHSP LAHTGGSMRV HSQSPPPPTT QPQLVARDHR QRQQQAPLAH
TSSSPGLERR RNFSPRQETT ATTTAAPSSH SASPTLSNSP SFSNHPVVLQ GNTQISHHPA
SPFAPIARTT SCGSRTSPSA ASAAAATASS LRSNSDVTAP TRPCAQSYHR PAVSPPPERQ
RAICSPCASA SNSSAVRQIP DDGESDGVQS TPEGPQPSRR RKDLAATYEE AWDVKMSRRL
GGMDVSRLAE ALPNSNFKRY DLVRASDRPL RSPATPAPVA RSPSLSPVLT STEGIVMRQP
RPAPRASFRN SSTDTVINRE MMPSPFRLKQ NRVASPTMNL SISPSVKEGP ASPSALAAPV
TDYDYAYNRS WSMGVQLNLS LNLASNTDGS ADQRVGPMAG EVGEKPVLSI SGASSPPPPP
PHRSASIMTP TTTQFSPPRS PTPMRRQCAI PHVTADVGVG MSPPSSRTRG VHNPLASGVP
IPLTPSSPPS EESSSTMRGD TSDAASTAAT VAVPGLLPHM SRLLADWDNM STDSCEEPWD
VRHGKVISQL TSSRFIDPSE VLSAVANGNH NGAATGASGG GVSNGHSKGR VAAGLVMDGE
GAVPMSPSSN ISQPISCPSP LARSPSDVKT QNCLKPLNEQ PWFHPNLTRF GAEKRLRSEP
EGSFLVRNSE TLKNEYSLTV KHNGFLHMRI TRDAQGQFVL GEYSQPYPSI PHMISHYEQT
QVPVKGADSV TLCHPR
//
