ID A0A087W1W6_ECHMU Unreviewed; 976 AA.
AC A0A087W1W6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN ORFNames=EmuJ_000240100 {ECO:0000313|EMBL:CDI98536.2};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDI98536.2};
RN [1] {ECO:0000313|EMBL:CDI98536.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDI98536.2}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN902844; CDI98536.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A087W1W6; -.
DR STRING; 6211.A0A087W1W6; -.
DR eggNOG; KOG1061; Eukaryota.
DR OMA; NPPEVQW; -.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 2.60.40.1150; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015151; B-adaptin_app_sub_C.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR PANTHER; PTHR11134:SF3; AP COMPLEX SUBUNIT BETA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF09066; B2-adapt-app_C; 1.
DR PIRSF; PIRSF002291; AP_complex_beta; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM01020; B2-adapt-app_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF55711; Subdomain of clathrin and coatomer appendage domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002291};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR002291};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR002291}.
FT DOMAIN 744..856
FT /note="Clathrin adaptor alpha/beta/gamma-adaptin appendage
FT Ig-like subdomain"
FT /evidence="ECO:0000259|SMART:SM00809"
FT DOMAIN 865..975
FT /note="Beta-adaptin appendage C-terminal subdomain"
FT /evidence="ECO:0000259|SMART:SM01020"
SQ SEQUENCE 976 AA; 107559 MW; CB8D83BC792EA423 CRC64;
MKPWFQKVTN QAKTTDSKYF TTTKKGEIFE LKAELQSEKK EKKKEAVKKV IASMTVGKDV
SALFPDVMNC MQTDNLELKK LVYLYLMNYA KTQPDTSIMT VSTFVRDCDD PNPLIRALAV
RTMGCIRVEK ITAYYCDPLR KCLKDEDPYV RKTAAICVAK LYDIDPTLVE DNGFLELLKN
LLSDSNPMVV TNAVAAISEI LETTQSDAAI NLLKIDQQIV NKLLTALNEC NEWGQVFILD
AITEYTPSDE REARGIIERV MPRLQHANAA VVLSAVKVII RTLSFIDPVS DLAQTTSKKL
APPLVTLLSA EPEIQYVALR NINLISQKNK DLLKQEIKAF FVKYNDPIYV KLEKLDIMIR
LTNQANIAHV LAELKEYAKE VDVDFVRKAV RAIGRCAIKV EASAERCVST LVELINTKVN
YVVQEAIVVI KDIFRKYPNK YESIIANLCE NLDTLDEPEA RASMIWIIGE YAERIDNADE
LLQSFLDGFH DENTQVQLQL LTAIVKLFLK RPSDTQELVQ NVLGLATLES DNPDLRDRGY
IYWRLLSTDP TAAKEVVLAE KPLISEETDL LEPSLLDELI CNLGSLASVY HQPPSAFVEG
KHISRKHLFA TSATASKAGE AGGPQQPTTT VIPTQETLIG DLLDIDAVPN TSLAPPVGYT
GTPIPGIDVE APDLLGDGLD DLLPGVPPKT SAAAPTGASE STADALADIF RGMRAGSGVS
STFTVPASHD LASIVMTPAA SSAYVPPPTT WLESSRGKGL EIAGTFSVSP STNQPQMELT
FTNNALSPMT GFAIQFNKNS FGLAPAQSLN VASPLQPKQP AKVILPLGFG NQVVKVDPLM
NLQVAVKNNV DVFYFACLVP IHVLFTAAGE MEKMVFLATW KDIPAENEQQ FVLTPLSLDA
DACSQKLRNN NVFTIAKRNV DGQDMLYQSI KLCNGIWVLA ELKIQPGNPS YTLSLKSREM
DVHPYVREAF HGILSN
//
