ID A0A087W1Z5_ECHMU Unreviewed; 1326 AA.
AC A0A087W1Z5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=EmuJ_000242500 {ECO:0000313|EMBL:CDI98560.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDI98560.1};
RN [1] {ECO:0000313|EMBL:CDI98560.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDI98560.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; LN902844; CDI98560.1; -; Genomic_DNA.
DR STRING; 6211.A0A087W1Z5; -.
DR eggNOG; KOG0921; Eukaryota.
DR OMA; RFKCELR; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd19854; DSRM_DHX9_rpt1; 1.
DR CDD; cd19855; DSRM_DHX9_rpt2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044445; DHX9_DSRM_1.
DR InterPro; IPR044446; DHX9_DSRM_2.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 6..76
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 171..244
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 401..567
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 646..817
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1262..1326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1326 AA; 150165 MW; DB015DE824E99D81 CRC64;
MSDAEGIKTF VYTWLHKSQR KVPEYTFQQR SMGRGRLRFI CELRVDGFAY IGVGNSVNKK
DAQTNAARDF ASFLVREGYL KESEVPTIRA EEYRHLADED RHCAAMYPST SSSGAMHPSY
HPPHLQVNET DVPGRGPNDS YINRIMDRIK LEEAEGIDLT ADIHGGWSME NSKARLNEYL
QASRQPPVQI KFTSIGPDHN KSFLAEATVW ARRVNKTLYA RENGSNKTMA SRACCLSLVR
QLFHVGEIEA YCGERKRKRS DDLPPLAVKL NPDLENRLHA LLERLHLVPN LSPPVPPLKT
GRTAVGSSEE EHNMIMNYQV ADFEPRPRQS AQLISWCPPI ENWNPWTAYN IDEGPEALMS
LAQLSQTYKE QYERRINSRA YEVIREERNS LPVAAFSQQI LDTIAGNQVT LIKGETGCGK
TTQIPQFILD SYLASSRGAE CSVLVTQPRR ICAISLAERV ASERCETVGI SVGYSVRFET
ILPRPYGSIL FCTIGTFCRK MEAGIRGVSH IIVDEIHERD VNTDFVMILM RDLVRANPSL
RVILMSATID TTTFTEYFDN TATVELEGRT YPVSCFYLED CINMTNYVPP PIYNEKKNKK
PRLEEELTMD TEENCNFICP PGYPPSVAER MRQIPEKEVP FTLIGGLLEY ICRMNIDGAV
LIFLPGWNTI SMLRKYLQTH PCFSNPNEFL ILPLHSQVPR EDQRLVFRPA PPGIRKIVLS
TNIAESSITI NDVVFVIDTC LARVKMFTAR NNLTSYSTMW ASLTNLEQRR GRAGRVRAGF
AYHLCSRARL SRLEHYATPE ILRTPLHELA LMIKLLRLGD IQTFLRKALQ SPPLDAVIEA
EYTLREMKAL DSNDELTPLG HILARLPIEP RLGRMLVFSC AFRLGGAMAL VAAHSSFGCD
VLAMPPDRRR LSWEQLRFAA TTNSDHLAML NAFQVWSTKR AQDGDQAANY FCDVRELNAF
SLRIIDEAAH QICNILMGLG FPESVLSDRL INFNNRSCST FDYVAAMLTN GLYPNIAYHV
EKRKLLTAEG KCALVHKGSV NCTKNPTFTF PLFAFTEKIR TQAISCKTLT MVTPIQLLLF
GCRRGVWKPK STGLESARSD ERRVALMEEE GVVLLDDWLP FRMRYSTAAR IFALRPALEA
LLVRVCLRPA CLENLSPEDR SVIELTKELC RHTALRDAAT LDEATHSTCA RFNADSRCPL
PTDTRRQIGP PEMSATSFDW DESQSLGWGY REWQDEWSHT SSNAGNPPPY CVHAGVHGTK
RDYPWPNRET YIPQNYGDRS GSLPQSAGHY AEPPLRHEKL DYGYEPTLSR PPGPRSLRKP
RPPYPY
//