ID A0A087W252_ECHMU Unreviewed; 942 AA.
AC A0A087W252;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Fch and double sh3 domains protein 2 {ECO:0000313|EMBL:CDI98711.1};
GN ORFNames=EmuJ_000257850 {ECO:0000313|EMBL:CDI98711.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDI98711.1};
RN [1] {ECO:0000313|EMBL:CDI98711.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDI98711.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902844; CDI98711.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087W252; -.
DR STRING; 6211.A0A087W252; -.
DR eggNOG; KOG3565; Eukaryota.
DR OMA; TPMMEEP; -.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR PANTHER; PTHR15735:SF20; PROTEIN NERVOUS WRECK; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 2.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..282
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 577..639
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 689..763
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 456..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 151..210
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 459..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 942 AA; 103684 MW; CDB22BC5A978B8EB CRC64;
MQDSTKKSQL KYIQSEHFSR LLSKQNNETE LLEDMRSFCK QRAILDKEYG QALQKLCSSF
LSKKEFLALP NPPNTGHRSV WDIWKLFLQE FNALALSHLK LAEVHHRLSL ELKPVKSLRV
AVSKRIFEQL KSLQNDLAAS MQEMVKSQKI YSEEEKQAHE TRLKAMNIED KLRRRSTNLF
STMAQLHRNH AKISQRRDEY ENRSAGARNE YLFQLTAINA HLDHYLKTDI PDLAQILDGD
VYDRFREVLS KTSEMELEIC RHHQDPFKAL LEESSKINRK TAWENFIKEL PIFSADVEFH
FEPRDGDTIS SLLSVNAKEG SFEQVAKKLA RRFVTRERRI KSYRQEINDL CSGRISPSPG
MSVSLSQVPS PPRKFPLKDC DTSEDSGALN QEYVENKVEE LEFAIRREEI EKTKISACLE
LLKKTHVDVQ AALYEANLAA TEVRTGTVGR GMEVAEKAQH GASSSSTAAT GSSSTEGSTV
GLTGLLTDST KHRNSFLLEN AFAPLNSFIP RSCTQNGGIS RTSAQQLANE AWAQANAASP
GANDEPSFIQ LDDEDPPSQQ QPSRREPSPE VDWTGGGQLP KATAMYEFLA ARSDEINMVC
NERVVLLGTG DGEDWVKVRS LLDGKAGLVP RAFLSIDPTP PPAPPHPAVP ALAAKSDTEQ
EPSDKTPLSP TSSPSEPVAL PHLPVEQCLA GQFVRALIDF AGTAEDELSF GVGAVIHVLG
QPAAGEVDDG WIEGELVPLT DAETTTPPAC GVFPSMLVET VTPEDIWQRR LSASRPRPAK
ALLSTGSTAD AKVSPSGERR CKPLSSSGSV PSPRLSNSAS RSKSRSASAK RSWGGGGSGG
PRRSTVSHNT SSSHRSSHRQ QQQQQQHHGQ QGRETSTGHG RVSRSLVSAK VTPSQASLSS
AEAHPPASTH QQQEPSPFIA NKEGRIGPNQ TYGNEELQIA EL
//
