ID A0A087W2M2_ECHMU Unreviewed; 1111 AA.
AC A0A087W2M2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Ras GTP exchange factor {ECO:0000313|EMBL:CDI98750.1};
GN ORFNames=EmuJ_000262100 {ECO:0000313|EMBL:CDI98750.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDI98750.1};
RN [1] {ECO:0000313|EMBL:CDI98750.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDI98750.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902850; CDI98750.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A087W2M2; -.
DR STRING; 6211.A0A087W2M2; -.
DR eggNOG; KOG3417; Eukaryota.
DR OMA; DHIPKVC; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF355; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 1..102
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 895..1111
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 213..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1111 AA; 124804 MW; 56BAC1ADF2A58A8A CRC64;
MLLPMLGVYQ EYVRNHHYSL QVLAEYKLRE EFTRALKRCE EKSQCEGRSI ESFLTTPMYQ
IPRYLVTLHE ILAHTPHEHV DRTNLEYAKR KLETLSQVIH DEVSETENIR KNLAIERMIS
DGCDILLDAN QVFVRQGALV QVTMNKATYP CPRITQLSSS SFEKKERLRQ VFLFTNHLLI
ATRTNSGRLK LAKKNGKIPL QGCALIEEMG FDLSQDESGH GSPPPNDTPE SGLSSVSRTQ
SVNSFGGQED LIPMEPQQQQ QQQQPTLPSP SWNLIPSKLA HGSLMLAALT LGTTGGDYAG
KFKRETRTGS LNRKNVADDS GDDSPTQIAS LMSTSPSTST APYLGSYRNL AFQITWPGDE
EETCSIWLVA SNLQEKEAWC SDISQCIEQL HYSDMLSIAH SEVSSISMPY SVRLDPGLFK
DCPDIKYRST RNSCKMPQYM VEVIVDPSFC LVKVRHGTLG RLLDRLLDPR FQSIDYLNTF
LLTYRVFTTG LTIIAVLRCV LRDPSLQLAS TKIDLDLLES MLQARPGVRR ASQQHNDSLP
FTGIKGGRRV STGMIDATRH QVFFPRRNLA TEKVLEEEEH ESGDSESEED IETRRIKSAS
EADKLRKFLF SEAPRGSSKE GIKNISHDIV KKAEELASNA ENQSAVVPDL PIIESRSVSA
SAPNRNSLTR QRSRVSYTCD TPTYRRAPRA GAIITSARLS RRRSSNWAAV KAFAIATAAS
SSTRMSHQRR ISATHRSPMT TAATTAITSS ITPTTAVAST SHFGETPPVT TMASVASWMT
PKEESPFLRL TTSSGEGGRE EKVASMTVLR VLNVARHWIT KYPEDFDGNA QLKSKMQVLL
EELLRNPRLN VSNRKVAFQL SREMLNDQLV ESHVDLDLLM TPSQVPSKEN FDKIPALDIA
EELTYLDFHI FRSIKTQELL NQVWMKDGKE TKAPHVMLVT KRFNEVSKLV VSEIISRSEI
PDRAACIEKW IAIADICRCL QNYNGVLQIC AALENSSVHR LKATWEVVAK QSKQSFEKLL
TLVAATARFK NLRELLHRYV DKYHQRVEVV FAGSESVVFF SCDPPCIPYL GMYLTDLSFI
GEGALDITEH GLINFCKMRM VVLIFKVTVA F
//
