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Database: UniProt
Entry: A0A087WNV1_MOUSE
LinkDB: A0A087WNV1_MOUSE
Original site: A0A087WNV1_MOUSE 
ID   A0A087WNV1_MOUSE        Unreviewed;       521 AA.
AC   A0A087WNV1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   SubName: Full=ArfGAP with FG repeats 1 {ECO:0000313|Ensembl:ENSMUSP00000139503.2};
GN   Name=Agfg1 {ECO:0000313|Ensembl:ENSMUSP00000139503.2,
GN   ECO:0000313|MGI:MGI:1333754};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000139503.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:17242355}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [2] {ECO:0007829|PubMed:19144319}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000139503.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000139503.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [5] {ECO:0000313|Ensembl:ENSMUSP00000139503.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000139503.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   RefSeq; XP_006496503.1; XM_006496440.3.
DR   AlphaFoldDB; A0A087WNV1; -.
DR   EPD; A0A087WNV1; -.
DR   jPOST; A0A087WNV1; -.
DR   ProteomicsDB; 348952; -.
DR   Antibodypedia; 1598; 248 antibodies from 31 providers.
DR   DNASU; 15463; -.
DR   Ensembl; ENSMUST00000187899.7; ENSMUSP00000139503.2; ENSMUSG00000026159.14.
DR   GeneID; 15463; -.
DR   AGR; MGI:1333754; -.
DR   CTD; 3267; -.
DR   MGI; MGI:1333754; Agfg1.
DR   VEuPathDB; HostDB:ENSMUSG00000026159; -.
DR   GeneTree; ENSGT00940000155511; -.
DR   OrthoDB; 2891604at2759; -.
DR   BioGRID-ORCS; 15463; 0 hits in 79 CRISPR screens.
DR   ChiTaRS; Agfg1; mouse.
DR   Proteomes; UP000000589; Chromosome 1.
DR   Bgee; ENSMUSG00000026159; Expressed in placenta labyrinth and 262 other cell types or tissues.
DR   ExpressionAtlas; A0A087WNV1; baseline and differential.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   CDD; cd08857; ArfGap_AGFG1; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 3.30.450.50; Longin domain; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   PANTHER; PTHR46134:SF1; ARF-GAP DOMAIN AND FG REPEAT-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR46134; DRONGO, ISOFORM F; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
PE   1: Evidence at protein level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Proteomics identification {ECO:0007829|EPD:A0A087WNV1,
KW   ECO:0007829|MaxQB:A0A087WNV1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00288}.
FT   DOMAIN          11..135
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REGION          170..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  53975 MW;  D5F2F5DA6ADEC65B CRC64;
     MAASAKRKQE EKHLKMLRDM TGLPHNRKCF DCDQRGPTYV NMTVGSFVCT SCSGSLRGLN
     PPHRVKSISM TTFTQQEIEF LQKHGNEVCK QIWLGLFDDR SSAIPDFRDP QKVKEFLQEK
     YEKKRWYVPP EQAKVVASVH ASISGSSASS TSSTPEVKPL KSLLGESAPA LHLNKGTPSQ
     SPVVGRSQGQ QQEKKQFDLL SDLGSDIFAA PAPQSTATAN FANFAHFNSH AGGSAGSVNA
     NFAHFDNFPK SSSADFGTFS TSQSHQTAST VSKVSTNKAG LQTADKYAAL ANLDNIFSAG
     QGGDQGSGFG TTGKAPVGSV VSVPSHSSAS SDKYAALAEL DSVFSSAATS SNAYTPTSNA
     SSSVFGTVPV GASAQTQPAS SGPAPFGATP STNPFVAATG PSAASSTNPF QTNARGATAA
     TFGTASMSMP AGFGTPAQYS LPTSFSGSFQ QPAFPAQAAF PQQTAFSQQP NGAGFATFGQ
     TKPVVTPFGQ VAAAGVSSNP FMTGAPTGQL PTGSSSTNPF L
//
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