ID A0A087WQD9_MOUSE Unreviewed; 235 AA.
AC A0A087WQD9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Nuclear envelope integral membrane protein 2 {ECO:0000313|Ensembl:ENSMUSP00000140152.2};
GN Name=Nemp2 {ECO:0000313|Ensembl:ENSMUSP00000140152.2,
GN ECO:0000313|MGI:MGI:2444113};
GN Synonyms=Tmem194b {ECO:0000313|MGI:MGI:2444113};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000140152.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000140152.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140152.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000140152.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140152.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004575}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004575}; Nucleoplasmic side
CC {ECO:0000256|ARBA:ARBA00004575}.
CC -!- SIMILARITY: Belongs to the NEMP family.
CC {ECO:0000256|ARBA:ARBA00005748}.
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DR AlphaFoldDB; A0A087WQD9; -.
DR ProteomicsDB; 326965; -.
DR Antibodypedia; 77970; 5 antibodies from 5 providers.
DR Ensembl; ENSMUST00000188507.7; ENSMUSP00000140152.2; ENSMUSG00000043015.16.
DR AGR; MGI:2444113; -.
DR MGI; MGI:2444113; Nemp2.
DR VEuPathDB; HostDB:ENSMUSG00000043015; -.
DR GeneTree; ENSGT00390000002174; -.
DR ChiTaRS; Nemp2; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000043015; Expressed in ureter smooth muscle and 138 other cell types or tissues.
DR ExpressionAtlas; A0A087WQD9; baseline and differential.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019358; NEMP_fam.
DR PANTHER; PTHR13598:SF3; NUCLEAR ENVELOPE INTEGRAL MEMBRANE PROTEIN 2; 1.
DR PANTHER; PTHR13598; UNCHARACTERIZED; 1.
DR Pfam; PF10225; NEMP; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:A0A087WQD9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..235
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001831809"
FT TRANSMEM 151..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 235 AA; 26555 MW; 2D3968437B6C88D2 CRC64;
MLPRLWWLVL WLQPLATLPA SAVHDEEAAM SVPRCKSLKE TDLIKTSVSD CYCYNQHSQI
QWTYMWSTVQ VTVTSPGLLN IVYITGSHNC QHTESILSFI KCVTHNFWAP EEAEEITIVF
SPYGETVCFS VKPVGRLLPY IVSVSRNIVD FKLFLVFVTG IFLFLYAKTL SQSPVFYYSS
GTVLGILMTL VFVLLMAKKH IPKAMWWLLD FVALLPVTVT GLLLMRGAET FSCGP
//
