ID A0A087WT10_HUMAN Unreviewed; 143 AA.
AC A0A087WT10;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Centromere protein S {ECO:0000256|ARBA:ARBA00016400};
GN Name=CENPS-CORT {ECO:0000313|Ensembl:ENSP00000473401.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000473401.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000473401.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000473401.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the somatostatin family.
CC {ECO:0000256|ARBA:ARBA00008327}.
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DR EMBL; AL139424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001230697.1; NM_001243768.1.
DR AlphaFoldDB; A0A087WT10; -.
DR SMR; A0A087WT10; -.
DR STRING; 9606.ENSP00000383692; -.
DR MassIVE; A0A087WT10; -.
DR PaxDb; 9606-ENSP00000383692; -.
DR PeptideAtlas; A0A087WT10; -.
DR Antibodypedia; 76505; 8 antibodies from 2 providers.
DR DNASU; 100526739; -.
DR Ensembl; ENST00000602296.6; ENSP00000473401.2; ENSG00000251503.8.
DR GeneID; 100526739; -.
DR UCSC; uc021ogf.1; human.
DR CTD; 100526739; -.
DR GeneCards; CENPS-CORT; -.
DR HGNC; HGNC:38843; CENPS-CORT.
DR VEuPathDB; HostDB:ENSG00000251503; -.
DR eggNOG; ENOG502S2ZK; Eukaryota.
DR BioGRID-ORCS; 100526739; 24 hits in 1009 CRISPR screens.
DR ChiTaRS; CENPS-CORT; human.
DR GenomeRNAi; 100526739; -.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000251503; Expressed in left testis and 98 other cell types or tissues.
DR ExpressionAtlas; A0A087WT10; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0071821; C:FANCM-MHF complex; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR029003; CENP-S/Mhf1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR004250; Somatostatin.
DR InterPro; IPR018142; Somatostatin/Cortistatin_C.
DR PANTHER; PTHR10558:SF1; CORTISTATIN; 1.
DR PANTHER; PTHR10558; SOMATOSTATIN; 1.
DR Pfam; PF15630; CENP-S; 1.
DR Pfam; PF03002; Somatostatin; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A087WT10,
KW ECO:0007829|MaxQB:A0A087WT10};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 129..142
FT /note="Somatostatin/Cortistatin C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03002"
SQ SEQUENCE 143 AA; 16498 MW; 60DA7705C862FA6B CRC64;
MSSRRGSFLS TKLHCSSCLP CPLSFEKFKP SEKLQEHENF AKDLEMFARH AKRTTINTED
VKLLARRSNS LHMQEAAGIR KSSLLTFLAW WFEWTSQASA GPLIGEEARE VARRQEGAPP
QQSARRDRMP CRNFFWKTFS SCK
//
