ID A0A087WTJ2_HUMAN Unreviewed; 511 AA.
AC A0A087WTJ2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=GIMAP1-GIMAP5 readthrough {ECO:0000313|Ensembl:ENSP00000477920.1};
GN Name=GIMAP1-GIMAP5 {ECO:0000313|Ensembl:ENSP00000477920.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000477920.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000477920.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000477920.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000256|ARBA:ARBA00008535}.
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DR EMBL; AC006479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001186506.1; NM_001199577.1.
DR AlphaFoldDB; A0A087WTJ2; -.
DR SMR; A0A087WTJ2; -.
DR STRING; 9606.ENSP00000477920; -.
DR BioMuta; GIMAP1-GIMAP5; -.
DR MassIVE; A0A087WTJ2; -.
DR PeptideAtlas; A0A087WTJ2; -.
DR DNASU; 100527949; -.
DR Ensembl; ENST00000611999.4; ENSP00000477920.1; ENSG00000281887.3.
DR GeneID; 100527949; -.
DR KEGG; hsa:100527949; -.
DR UCSC; uc022apw.1; human.
DR AGR; HGNC:51257; -.
DR CTD; 100527949; -.
DR GeneCards; GIMAP1-GIMAP5; -.
DR HGNC; HGNC:51257; GIMAP1-GIMAP5.
DR MalaCards; GIMAP1-GIMAP5; -.
DR VEuPathDB; HostDB:ENSG00000281887; -.
DR HOGENOM; CLU_533115_0_0_1; -.
DR OMA; YMENHES; -.
DR OrthoDB; 938643at2759; -.
DR BioGRID-ORCS; 100527949; 8 hits in 201 CRISPR screens.
DR ChiTaRS; GIMAP1-GIMAP5; human.
DR GenomeRNAi; 100527949; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A0A087WTJ2; Protein.
DR Bgee; ENSG00000281887; Expressed in granulocyte and 97 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01852; AIG1; 1.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10903:SF180; GTPASE IMAP FAMILY MEMBER 5; 1.
DR PANTHER; PTHR10903; GTPASE, IMAP FAMILY MEMBER-RELATED; 1.
DR Pfam; PF04548; AIG1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51720; G_AIG1; 2.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|MaxQB:A0A087WTJ2,
KW ECO:0007829|PeptideAtlas:A0A087WTJ2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 484..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..226
FT /note="AIG1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51720"
FT DOMAIN 229..432
FT /note="AIG1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51720"
SQ SEQUENCE 511 AA; 57052 MW; 2D96AA87578D9D6C CRC64;
MGGRKMATDE ENVYGLEENA QSRQESTRRL ILVGRTGAGK SATGNSILGQ RRFFSRLGAT
SVTRACTTGS RRWDKCHVEV VDTPDIFSSQ VSKTDPGCEE RGHCYLLSAP GPHALLLVTQ
LGRFTAQDQQ AVRQLSHGAF SPSTWLLLNC VCSTSLSPVN SIPAHRRRAG LSLLPLHLPE
RGPAARASVT ATLEDRAQQP FLERMGGFQR GKYGTMAEGR SEDNLSATPP ALRIILVGKT
GCGKSATGNS ILGQPVFESK LRAQSVTRTC QVKTGTWNGR KVLVVDTPSI FESQADTQEL
YKNIGDCYLL SAPGPHVLLL VIQLGRFTAQ DTVAIRKVKE VFGTGAMRHV VILFTHKEDL
GGQALDDYVA NTDNCSLKDL VRECERRYCA FNNWGSVEEQ RQQQAELLAV IERLGREREG
SFHSNDLFLD AQLLQRTGAG ACQEDYRQYQ AKVEWQVEKH KQELRENESN WAYKALLRVK
HLMLLHYEIF VFLLLCSILF FIIFLFIFHY I
//