ID A0A087WVY3_HUMAN Unreviewed; 251 AA.
AC A0A087WVY3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Replication factor C subunit 2 {ECO:0000313|Ensembl:ENSP00000479768.1};
GN Name=RFC2 {ECO:0000313|Ensembl:ENSP00000479768.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000479768.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000479768.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2] {ECO:0007829|PubMed:19608861}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [3] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [4] {ECO:0000313|Ensembl:ENSP00000479768.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC005081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001265721.1; NM_001278792.1.
DR AlphaFoldDB; A0A087WVY3; -.
DR SMR; A0A087WVY3; -.
DR MassIVE; A0A087WVY3; -.
DR PeptideAtlas; A0A087WVY3; -.
DR Antibodypedia; 14601; 556 antibodies from 33 providers.
DR DNASU; 5982; -.
DR Ensembl; ENST00000621097.4; ENSP00000479768.1; ENSG00000049541.11.
DR GeneID; 5982; -.
DR UCSC; uc032zrr.2; human.
DR CTD; 5982; -.
DR HGNC; HGNC:9970; RFC2.
DR VEuPathDB; HostDB:ENSG00000049541; -.
DR GeneTree; ENSGT00550000075050; -.
DR HOGENOM; CLU_042324_0_2_1; -.
DR OrthoDB; 275853at2759; -.
DR BioGRID-ORCS; 5982; 735 hits in 1167 CRISPR screens.
DR ChiTaRS; RFC2; human.
DR GenomeRNAi; 5982; -.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000049541; Expressed in ventricular zone and 154 other cell types or tissues.
DR ExpressionAtlas; A0A087WVY3; baseline and differential.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013748; Rep_factorC_C.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR PANTHER; PTHR11669:SF5; REPLICATION FACTOR C SUBUNIT 2; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF08542; Rep_fac_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|EPD:A0A087WVY3,
KW ECO:0007829|MaxQB:A0A087WVY3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 155..240
FT /note="Replication factor C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08542"
SQ SEQUENCE 251 AA; 28377 MW; D094805B36DECB6D CRC64;
MCPTSSLRGI DVVRNKIKMF AQQKVTLPKG RHKIIILDEA DSMTDGAQQA LRRTMEIYSK
TTRFALACNA SDKIIEPIQS RCAVLRYTKL TDAQILTRLM NVIEKERVPY TDDGLEAIIF
TAQGDMRQAL NNLQSTFSGF GFINSENVFK VCDEPHPLLV KEMIQHCVNA NIDEAYKILA
HLWHLGYSPE DIIGNIFRVC KTFQMAEYLK LEFIKEIGYT HMKIAEGVNS LLQMAGLLAR
LCQKTMAPVA S
//
