ID A0A087X0H5_HUMAN Unreviewed; 645 AA.
AC A0A087X0H5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Growth hormone receptor {ECO:0000256|ARBA:ARBA00017448};
DE AltName: Full=Somatotropin receptor {ECO:0000256|ARBA:ARBA00031294};
GN Name=GHR {ECO:0000313|Ensembl:ENSP00000483403.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483403.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000483403.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000483403.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The soluble form (GHBP) acts as a reservoir of growth hormone
CC in plasma and may be a modulator/inhibitor of GH signaling.
CC {ECO:0000256|ARBA:ARBA00003894}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00007885}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC093225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC113368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC114941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC116343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC876969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF457892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001229328.1; NM_001242399.2.
DR AlphaFoldDB; A0A087X0H5; -.
DR SMR; A0A087X0H5; -.
DR MassIVE; A0A087X0H5; -.
DR PeptideAtlas; A0A087X0H5; -.
DR Antibodypedia; 23220; 492 antibodies from 36 providers.
DR DNASU; 2690; -.
DR Ensembl; ENST00000620156.4; ENSP00000483403.1; ENSG00000112964.14.
DR GeneID; 2690; -.
DR UCSC; uc021xxv.1; human.
DR CTD; 2690; -.
DR HGNC; HGNC:4263; GHR.
DR VEuPathDB; HostDB:ENSG00000112964; -.
DR GeneTree; ENSGT00940000159987; -.
DR OrthoDB; 5317462at2759; -.
DR BioGRID-ORCS; 2690; 10 hits in 1159 CRISPR screens.
DR ChiTaRS; GHR; human.
DR GenomeRNAi; 2690; -.
DR Proteomes; UP000005640; Chromosome 5.
DR Bgee; ENSG00000112964; Expressed in skeletal muscle tissue of rectus abdominis and 167 other cell types or tissues.
DR ExpressionAtlas; A0A087X0H5; baseline and differential.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:HPA.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0060396; P:growth hormone receptor signaling pathway; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR025871; GHBP.
DR InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003528; Long_hematopoietin_rcpt_CS.
DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23037:SF41; CYTOKINE RECEPTOR-LIKE FACTOR 2-RELATED; 1.
DR Pfam; PF09067; EpoR_lig-bind; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF12772; GHBP; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01352; HEMATOPO_REC_L_F1; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A087X0H5,
KW ECO:0007829|ProteomicsDB:A0A087X0H5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..645
FT /note="Growth hormone receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001832168"
FT TRANSMEM 271..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 158..261
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 360..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 645 AA; 72243 MW; D757356B10C5D250 CRC64;
MNWGPTGMDL WQLLLTLALA GSSDAFSGSE ATAAILSRAP WSLQSVNPGL KTNSSKEPKF
TKCRSPERET FSCHWTDEVH HGTKNLGPIQ LFYTRRNTQE WTQEWKECPD YVSAGENSCY
FNSSFTSIWI PYCIKLTSNG GTVDEKCFSV DEIVQPDPPI ALNWTLLNVS LTGIHADIQV
RWEAPRNADI QKGWMVLEYE LQYKEVNETK WKMMDPILTT SVPVYSLKVD KEYEVRVRSK
QRNSGNYGEF SEVLYVTLPQ MSQFTCEEDF YFPWLLIIIF GIFGLTVMLF VFLFSKQQRI
KMLILPPVPV PKIKGIDPDL LKEGKLEEVN TILAIHDSYK PEFHSDDSWV EFIELDIDEP
DEKTEESDTD RLLSSDHEKS HSNLGVKDGD SGRTSCCEPD ILETDFNAND IHEGTSEVAQ
PQRLKGEADL LCLDQKNQNN SPYHDACPAT QQPSVIQAEK NKPQPLPTEG AESTHQAAHI
QLSNPSSLSN IDFYAQVSDI TPAGSVVLSP GQKNKAGMSQ CDMHPEMVSL CQENFLMDNA
YFCEADAKKC IPVAPHIKVE SHIQPSLNQE DIYITTESLT TAAGRPGTGE HVPGSEMPVP
DYTSIHIVQS PQGLILNATA LPLPDKEFLS SCGYVSTDQL NKIMP
//
