ID A0A087X0J4_HUMAN Unreviewed; 134 AA.
AC A0A087X0J4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Aspartate beta-hydroxylase {ECO:0000313|Ensembl:ENSP00000483443.1};
DE Flags: Fragment;
GN Name=ASPH {ECO:0000313|Ensembl:ENSP00000483443.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483443.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000483443.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000483443.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC067881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; A0A087X0J4; -.
DR PeptideAtlas; A0A087X0J4; -.
DR Antibodypedia; 24707; 365 antibodies from 30 providers.
DR Ensembl; ENST00000519678.5; ENSP00000483443.1; ENSG00000198363.18.
DR UCSC; uc064nes.1; human.
DR HGNC; HGNC:757; ASPH.
DR VEuPathDB; HostDB:ENSG00000198363; -.
DR GeneTree; ENSGT00940000156304; -.
DR ChiTaRS; ASPH; human.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000198363; Expressed in calcaneal tendon and 202 other cell types or tissues.
DR ExpressionAtlas; A0A087X0J4; baseline and differential.
DR GO; GO:0062101; F:peptidyl-aspartic acid 3-dioxygenase activity; IEA:InterPro.
DR InterPro; IPR039038; ASPH.
DR PANTHER; PTHR12366; ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE; 1.
DR PANTHER; PTHR12366:SF33; ASPARTYL_ASPARAGINYL BETA-HYDROXYLASE; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A087X0J4,
KW ECO:0007829|ProteomicsDB:A0A087X0J4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000483443.1"
SQ SEQUENCE 134 AA; 15493 MW; 09D330D3D0DF2471 CRC64;
XEDLQQEDGP TGEPQQEDDE FLMATDVDDR FETLEPEVSH EETEHSYHVE ETVSQDCNQD
MEEMMSEQEN PDSSEPVVED ERLHHDTDDV TYQVYEEQEV TAPPEDNPVE DSQVIVEEVS
IFPVEEQQEV PPDT
//
