ID A0A087X277_HUMAN Unreviewed; 419 AA.
AC A0A087X277;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=SOS Ras/Rho guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSP00000484766.1};
DE Flags: Fragment;
GN Name=SOS2 {ECO:0000313|Ensembl:ENSP00000484766.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484766.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000484766.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000484766.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL109758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; A0A087X277; -.
DR PeptideAtlas; A0A087X277; -.
DR Antibodypedia; 3885; 183 antibodies from 28 providers.
DR Ensembl; ENST00000555794.2; ENSP00000484766.1; ENSG00000100485.12.
DR UCSC; uc059big.1; human.
DR HGNC; HGNC:11188; SOS2.
DR VEuPathDB; HostDB:ENSG00000100485; -.
DR GeneTree; ENSGT00940000158324; -.
DR HOGENOM; CLU_658147_0_0_1; -.
DR ChiTaRS; SOS2; human.
DR Proteomes; UP000005640; Chromosome 14.
DR Bgee; ENSG00000100485; Expressed in vastus lateralis and 212 other cell types or tissues.
DR ExpressionAtlas; A0A087X277; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Proteomics identification {ECO:0007829|MaxQB:A0A087X277,
KW ECO:0007829|PeptideAtlas:A0A087X277};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 146..249
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 300..419
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000484766.1"
SQ SEQUENCE 419 AA; 49106 MW; 5E0244341D48D4E6 CRC64;
XSQDILSPEF HEHFNKLMAR PAVALHFQSI ADGFKEAVRY VLPRLMLVPV YHCWHYFELL
KQLKACSEEQ EDRECLNQAI TALMNLQGSM DRIYKQYSPR RRPGDPVCPF YSHQLRSKHL
AIKKMNEIQK NIDGWEGKDI GQCCNEFIME GPLTRIGAKH ERHIFLFDGL MISCKPNHGQ
TRLPGYSSAE YRLKEKFVMR KIQICDKEDT CEHKHAFELV SKDENSIIFA AKSAEEKNNW
MAALISLHYR STLDRMLDSV LLKEENEQPL RLPSPEVYRF VVKDSEENIV FEDNLQSRSG
IPIIKGGTVV KLIERLTYHM YADPNFVRTF LTTYRSFCKP QELLSLLIER FEIPEPEPTD
ADKLAIEKGE QPISADLKRF RKEYVQPVQL RFGLNIFYIY IYTHIYTHTH TFYVSVFNI
//
