ID A0A087X3E6_POEFO Unreviewed; 377 AA.
AC A0A087X3E6;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Alcohol dehydrogenase 1-like {ECO:0000313|Ensembl:ENSPFOP00000000299.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000000299.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000000299.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; AYCK01026021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007543930.1; XM_007543868.2.
DR AlphaFoldDB; A0A087X3E6; -.
DR STRING; 48698.ENSPFOP00000000299; -.
DR Ensembl; ENSPFOT00000000300.2; ENSPFOP00000000299.2; ENSPFOG00000000303.2.
DR GeneID; 103132123; -.
DR KEGG; pfor:103132123; -.
DR eggNOG; KOG0022; Eukaryota.
DR GeneTree; ENSGT00940000164529; -.
DR OMA; GWTDMEN; -.
DR OrthoDB; 3826644at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:UniProt.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF3; ALCOHOL DEHYDROGENASE 8A-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 17..372
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 377 AA; 40446 MW; 5D7A184C7ED75898 CRC64;
MATAGQVIRC KAAVAWEFNQ PLVIEEVEVA PPQEKEIRIK IVATGVCQSD LYFLSKCSNQ
TAFPVVFGHE AAGVVESIGP GVTEFQPGDT VIPLFMPQCR ECRLCKSPKT NLCVNGSAGK
IDERSFERSR ISCRGRKLLQ FLGTSSFSEF TVVKEMSVAK IDPAAPLDRV CLIGCAICTG
YGAAVNTAKV EAGSSCAVFG LGAVGLAAVM GCKAAGASRI IAIDINPDKF EKAKVLGATD
VVNPNDHSRP IQQLLQEMTG GGVDFSFECI GNVEVMRSAL ESCAPGWGVS VIAGWTDMEN
FSAPPIHLMT GRKWTGTLFG GFKGKDGVAQ MVKAYLDRKL MVDEFITHNL RLEQINEAVE
LMKNGRCIRA VLSVSPQ
//
