ID A0A087X3W4_POEFO Unreviewed; 587 AA.
AC A0A087X3W4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Mucolipin-1-like {ECO:0000313|Ensembl:ENSPFOP00000000467.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000000467.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000000467.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AYCK01013040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007569610.1; XM_007569548.2.
DR AlphaFoldDB; A0A087X3W4; -.
DR STRING; 48698.ENSPFOP00000000467; -.
DR Ensembl; ENSPFOT00000000468.2; ENSPFOP00000000467.2; ENSPFOG00000000348.2.
DR GeneID; 103150090; -.
DR KEGG; pfor:103150090; -.
DR eggNOG; KOG3733; Eukaryota.
DR GeneTree; ENSGT00950000183036; -.
DR OrthoDB; 2877219at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR GO; GO:0035675; P:neuromast hair cell development; IEA:Ensembl.
DR GO; GO:1902822; P:regulation of late endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0001895; P:retina homeostasis; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF6; MUCOLIPIN-1; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..295
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 394..531
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 587 AA; 67048 MW; 6A9D611078F8B275 CRC64;
MAATRRRNSS EHTGLFSSVT HYGSTENCSD HQANSNDSNC NKQNLSTAAA GHWVEADPEE
EAIRRKLKYF FMSPCDKYHA KGRKPFKLVL QVLKIFAVTA QLIVFGISNQ VAVTFKEENT
MTFKHLFLKD YDQSSDDSFA VYTQQDVYDH MFYAIEKYLT LPDNTVGRYA YVYHVGVNDS
ALSLCQQYYK KGQIDPANDT FSIDPRIVTD CIGVNPMSVP HNQLTSSYKN FTLKFHKLIN
VTIQFQLKAI NIQTIINNEI PDCYTFHITI VMDNKAHSGK VKIWLENKAM MRECKDPSVS
GHAESFTRVT FDVIVCLMCL LSLLLCGRSL LRGIILQQEF VKYFKDTLDR KVCWADRLEF
INGWYILLII SDIFTITGSI IKICIESKTT SSYDICAILL GTSTLLVWVG VIRYLTFFQK
YNILIITLRV AFPNVIRFCC CVAVIYLGYC FCGWIVLGPY HVKFRSLSMV SECLFSLING
DDMFVTFSEM QESSILVWAF SQIYLYTFIS LFIYMVLSLF IALITGAYET IKHQTQEPIH
ITDLHAFIAE CTDAPTSGKF RGVETSPCSF FCCCDRTTTY EDVLLVN
//
