ID A0A087X418_POEFO Unreviewed; 636 AA.
AC A0A087X418;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Phosphatidylinositol 3-kinase catalytic subunit type 3 {ECO:0000256|ARBA:ARBA00019787};
DE AltName: Full=Phosphoinositide-3-kinase class 3 {ECO:0000256|ARBA:ARBA00029930};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000000521.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000000521.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Midbody {ECO:0000256|ARBA:ARBA00004214}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; AYCK01009788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087X418; -.
DR STRING; 48698.ENSPFOP00000000521; -.
DR Ensembl; ENSPFOT00000000522.2; ENSPFOP00000000521.2; ENSPFOG00000000426.2.
DR eggNOG; KOG0904; Eukaryota.
DR GeneTree; ENSGT00940000164913; -.
DR OMA; KFMNSKM; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00872; PI3Ka_I; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR008290; PI3K_Vps34.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR PANTHER; PTHR10048:SF95; PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR PIRSF; PIRSF000587; PI3K_Vps34; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..55
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 84..261
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 332..618
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 636 AA; 74052 MW; 000DCC261114BC46 CRC64;
MDILVSGKVA LSLWPVPHGL EDLLNPIGVA GSNPNKETPC VELEFSRFNQ TVVFPDEQQI
EEHANWTISR ELGYNYCHGL SSRLACDSSV SAADAEQLRS LCSRDPLYEL SEQEKDFLWR
HRHYCLNIPE SLPKLLLSVK WNSRDEVSQM YCLLKEWPLM EPESALELLD CNFPDPIVRE
FALRCLVQGL TDDKLSQYLL QLVQVLKYEM YLDNPLARFL IKKALTNQRI GHFFFWHLKS
EMHNKTVSRR FGLLLEAFCR ACGMYLKHLN RQVEAMDKLV NLTDTLKQEK KDETQKTQMK
FLVEHMSRPD YMESLQGFVS PLNPVHQLGN LRLEECRIMS SAKRPLWLNW ENPDIMSELL
FTNNEIIFKN GDDLRQDMLT LQIIKIMENI WQNQGLDLRM LPYGCLSIGD RVGLIEVVKN
SYTIMQIQCK GGLKGALQFN SNTLHHWIKD KNHGEAYDRA IDLFTRSCAG YCVATFILGI
GDRHNSNIMV KENGQLFHID FGHFLDHKKK KFGYKRERVP FVLTQDFLIV ISKGIQESTK
TKEFERFQEM CYKAYLAIRQ HASLFINLFS LMLGCGMPEL QSFDDIAYLR KTLALEKSQQ
EALEYFTKQM NDAHHGGWST KMDWIFHTIR HMPNEH
//
