ID A0A087X4C9_POEFO Unreviewed; 967 AA.
AC A0A087X4C9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Si:ch73-74h11.1 {ECO:0000313|Ensembl:ENSPFOP00000000632.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000000632.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000000632.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of intercellular desmosome junctions. Involved in
CC the interaction of plaque proteins and intermediate filaments mediating
CC cell-cell adhesion. {ECO:0000256|RuleBase:RU004358}.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|RuleBase:RU003318}.
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DR EMBL; AYCK01021256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01021261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087X4C9; -.
DR STRING; 48698.ENSPFOP00000000632; -.
DR Ensembl; ENSPFOT00000000633.2; ENSPFOP00000000632.2; ENSPFOG00000000645.2.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT01030000234624; -.
DR OMA; PEPMIHG; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR009122; Desmosomal_cadherin.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR24025:SF1; DESMOGLEIN-2; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01818; DESMOCADHERN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 45..128
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 147..244
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 245..400
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 401..512
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 361..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 967 AA; 105514 MW; 2A17690EEE212D4A CRC64;
MISADANEKG LKTLKRTKRE WILPPAKLKE NHNYTHLEYI AKIRSDRDKE RKVEYSLTGA
GADKPPFNLF VVDHNTGFIR VTNILDREKC PSYNVGVTAA SDKIYHNIHK NTELKASFPS
STEHTTLLKH NKHKKSGNLL CICDSAGTFV MQIEGKDDDQ ADTINSKIVY TIISQEPAGK
GHMFSIDKET GKLFVKESTL DRETHDSYKL IIKGTDMGGA PSGKTGTGTV EIKVTDINDN
IPTLEKSEYA GSVDENVADV IVMKIKALDK DLPHTNNWLT VFTIAQGNED NLFSIETDKE
TNEGILKLIK PVDFEDVQNL ELGLIIENVA PFVEGGPVHM DVDVQVGEGG PLAAGAAAGA
GAGVGAGAGQ GSGPKPKPKA PGKSYPIKIA VNNVPEGPAF RPDTKKVPVS EDPNEAPTDG
VITSFPAVDP DTGKVADDVS YAKAYDPDNW FTVDKETAEI KLNKQPDRES PFLVNGTYIA
KILAISKDMP AKTATGTIAI QVTDSNDHCP TLTTTYNSLC SDKKTVYVTA FDEDVSPNAA
PFTFQIIPEG TRGNWEIEVI NDTTAALHSA KALWPGRYEL QVEVKDAQGL SCEEEQVFTV
DVCTCVGKED CRLKASRGDA RSSDFSRRAI GPVVTAMFLL MLVPLLLVFC QCGGANTIFS
DQFSDLPFDT KEHLINYQTE CIGEDKLVPV MYGTQQKTEA APGPNFNTGS SAAFTETLKT
ETYYESDQIF QPTSTKMVNA DIDYRVSTEF YNPSNEIDSF SRKTQSIHQD IGLPDVFLSD
YFSQKSTITV PSEDILLEYD FEGQGSSAGS VGSCSILEPD NDLNFLTDLG PKFRTLAEIC
SPPTLTSKTM VIQKASGSVK TTTDITEPVF KPKFNHEIQA NTATKESTTK QSTTTTLPHS
SSTNISHSAK LSYPAQTVVL QQPPVYYTAS PVLQPMHYIV QPNVQNTFVL EDGTHANTFP
GLYVIND
//
