ID A0A087X4L4_POEFO Unreviewed; 696 AA.
AC A0A087X4L4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Very low-density lipoprotein receptor-like {ECO:0000313|Ensembl:ENSPFOP00000000717.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000000717.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000000717.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; AYCK01026800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087X4L4; -.
DR STRING; 48698.ENSPFOP00000000717; -.
DR Ensembl; ENSPFOT00000000718.2; ENSPFOP00000000717.2; ENSPFOG00000000698.2.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000155460; -.
DR OMA; DEYACKN; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 5.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 5.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 620..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..40
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 207..246
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 210..246
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 247..286
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 250..286
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 378..420
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 421..464
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 465..509
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 558..601
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DISULFID 5..17
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 12..30
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 24..39
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 44..56
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 51..69
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 90..102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 97..115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 109..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 129..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 136..154
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 148..163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 177..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 696 AA; 76499 MW; 1BA92EEE1F5CD60F CRC64;
GNVTCALNEF TCASGRCISK NFVCNGEDDC GDGSDEVDCA PSSCAPNEFQ CGNASCIPAN
WVCDDDVDCQ DQSDEAPARC GRHPTPPAKC LSSEMQCSSG ECIHKKWRCD GDPDCKDGSD
EANCPARSCE PDKFKCDDGS CIQGSRQCNG YRDCDDGSDE INCKNLTQCN GPEKFKCRSG
ECIEMSKVCN KIRDCPDWSD EPINECNVNE CLLNNGGCSH ICKDMVIGFE CDCTPGLQLI
DHKTCGDINE CMNPGICSQI CINLKGGYKC ECHNGYQMDP ATSVCKAVGK EPCLIFTNRR
DIRRLGLERK EYTQIVEQQR NAAALDADFN QQTIFWADLG QRAIYSTVLD RRGDVGVHKK
VIDNVQTPLG IAVDWIYKNL YWSDLGTKTI SVANFNGTKR KVLFNTGLRE PASIAVDPLS
GFLYWSDWGE PAKIEKSGMN GADRQVLVAT DIQWPNGITL DLIKGRLYWV DSKLHMLSSV
DLNGDNRNKV LQSADYLAHP FAVTVFEDRV FWTDGENKAI YGANKFSGSD VVTLASNLND
PQDVIVYHEL IQLAGTNWCT EKNGGCSFLC LPAPQINKHS PKYSCVCPAG QELAADGQRC
RPEANVSTSI QVDSTTRGSA AAWAVLPVLL LAMAAAGAYL MWRNWQLKNQ KSMNFDNPVY
LKTTEEDLNI DITRHGANVG HTYPAISIVS TDDDLS
//
