UniProt: A0A087X4T8

Database: UniProt
Entry: A0A087X4T8_POEFO

LinkDB:  A0A087X4T8_POEFO 
Original site:  A0A087X4T8_POEFO

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Ontology (4)   
   GO (4)   
Gene (3)   
   ENSEMBL-UP (3)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (11)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (2)   
   SMART (1)   
All databases (19)   

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ID   A0A087X4T8_POEFO        Unreviewed;       739 AA.
AC   A0A087X4T8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000000791.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000000791.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of intercellular desmosome junctions. Involved in
CC       the interaction of plaque proteins and intermediate filaments mediating
CC       cell-cell adhesion. {ECO:0000256|RuleBase:RU004358}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC       {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC       {ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003318}.
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DR   EMBL; AYCK01021262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A087X4T8; -.
DR   Ensembl; ENSPFOT00000000793.2; ENSPFOP00000000791.2; ENSPFOG00000000749.2.
DR   GeneTree; ENSGT01030000234624; -.
DR   OMA; MFYIDRR; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 3.
DR   Gene3D; 2.60.40.60; Cadherins; 5.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   InterPro; IPR009122; Desmosomal_cadherin.
DR   PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR24025:SF1; DESMOGLEIN-2; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 3.
DR   PRINTS; PR00205; CADHERIN.
DR   PRINTS; PR01818; DESMOCADHERN.
DR   SMART; SM00112; CA; 4.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 4.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          9..90
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          91..198
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          199..315
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          316..426
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   739 AA;  82168 MW;  79A22F962336FF47 CRC64;
     LLLFQIRSDR QIGTNVIYSL EGIGANQPPF HVFVVDPHNG NVRVTRKLDR EEIPLYNLAG
     FAKFPNGTEA EAKIDLKIKV VDENDNGPTF ESSVLTAEVD EHSPIGSSVI TISATDKDED
     GTPHTKIAYY IIGQEPRDWF RMDKDGTIYV KNNLDREKEK TVLLTVTGRD MDGAPQGHIA
     TATVTINIRD VNDNPPTLES EAYEGDIEEN TFGVEVMRIK ANDLDSDQDN WEAVFEIVQG
     NEDGYFSIKT DPNTNEGILF LEKPVDFEDV KDMNLGLAVR NKAPLVDGTG GAWGSKFKTY
     PIKINVKNQP EGPHFEPKVK PIPIKEGTPI DVNKVIASYP AIDKDTGKPA EDVKYLKGSD
     PQNWLSIDPK TADIKLNKMP DRESPFLING VYMAEILCIT EGMPSKTATG TVAIQVEDLN
     DHCPTLTSNF IPMCKPNKRI IVNAKDEDAF PNGPPFKFSI YPGSTSVDWK MRPYNDTAVL
     LTTSDELHYS LNDLMLVVED QQKLTCPNPQ KLTVFTCDCT ETGDCSVKGS MKLLKPKTAL
     GPAGIGLLFL GLLAVLCESL ISSELKKLHE LLSHVKIPWS DLKCSRLCAD LMFHDHCQQQ
     LIQLLYHRKA WQRDAEKTFI DSFLKGYYNK DKCKIAPHMK CCSFRSGGSS NQNHATYTHL
     SLQFHPPNLL EGLFFTFNHT SGDEKIVQKD HMLVFDYEGT GSSAGSVGCC SNLQQDCDLE
     FLNNLGPSFK TLAEICGGK
//

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