ID A0A087X6L4_POEFO Unreviewed; 1392 AA.
AC A0A087X6L4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=PWWP domain-containing protein {ECO:0000259|PROSITE:PS50812};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000001417.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000001417.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HDGF family.
CC {ECO:0000256|ARBA:ARBA00005309}.
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DR EMBL; AYCK01012321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01012322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000001417; -.
DR Ensembl; ENSPFOT00000001420.2; ENSPFOP00000001417.2; ENSPFOG00000001481.2.
DR eggNOG; KOG1904; Eukaryota.
DR GeneTree; ENSGT00940000174394; -.
DR OMA; LQERWNQ; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd05834; PWWP_HRP; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR036218; HIVI-bd_sf.
DR InterPro; IPR021567; LEDGF_IBD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR PANTHER; PTHR12550; HEPATOMA-DERIVED GROWTH FACTOR-RELATED; 1.
DR PANTHER; PTHR12550:SF78; HEPATOMA-DERIVED GROWTH FACTOR-RELATED PROTEIN 3; 1.
DR Pfam; PF11467; LEDGF; 1.
DR Pfam; PF00855; PWWP; 1.
DR SUPFAM; SSF140576; HIV integrase-binding domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 11..64
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 91..1266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..1022
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1392 AA; 157989 MW; 7A96FECBE7CC19FE CRC64;
MSGKLGNPLK AGDLVFAKMK GFPHWPARVC KSENGYRKRV PVYFFGTHQI GSVTPENVAP
YVGNKLKYGS GVRIKGFAEG MWEIQNMPGL GSKLKVQPKT CTKKTPAKPA SSSTTLSKST
PASSRKTPAA KTPGGKPKGA SAPTKSECNT KPASSRSTPS RALAEKESSE RSTRTSFRSA
PDKTTQTKPD PDASDRPAAK RFSSRLTPDQ PVEAKQDKET LDRTTATRSS RLVQSVEPKL
DKETPDHVEA IRSSSRLSPD ENMNSELQRA PAAAGGLSKS DPGDFTQLTE SAERREVRLE
LIRLSSDETA ESRQREASRL APEKPTDSKL EKETRGAGTS SSGSAPDKTT ESKQVTEPAE
QPAAPRTSSR SAPEKPTGPK PDQEAGEVAT ATRSRRSASG GSLAERSTEK KTPAQTKREV
RSGRASSASD GKPAAGWTGS KPQAQKETEN SGEQEAAGRR VSTRSKATDL KFSDIPDLPP
CRKRRKDAGK RQNKEAKRKK EEEEKKEEEK LSPSSEDGMK DQTESGASKR KMEEEKTEEG
REKVKRRSEK DKEAGEKEMK RIKMRREEKS EGGNKRKADE EEREERKTSE KTNETHKEGA
EEINEKHEDK REETKVRRTE RERDSSEETK RGEKDEDKTE GIKTKKVQKD KEKTEGMKTK
SEEEMERTMT KKSKREEEKM ENKTRKTEKP EEKTEERGEG TKVRRDEKER KKEEEERVKT
RRAESKEQKD DKKTKKRRKG KKEEEDKPET NLEKMREMKK KTTKDGEKDV REERRREEKE
KKVQKKRKHE GMGEEEEKRG LQSARREEEE EVKKRKDGGE ETAEEKEDER QEQLAARRES
LIESLRDLLK TKEMTKSCQD GGKSADRKTP TKGGDKRRKG EKTDRGGKMS TRKSTTETKG
ERPSNQRTSS DMKTDGQKEE KTNEGTRRDK MATRKSTAER KKTRKRVEKD SRQSADKTER
EMRKTTEDKT GGKEEEMSTR GSAVEVKKDG QKVEKDETKE QTKSKEEDET KQQKDERKII
GKIVKANQGT KIHVKTMMGG LTKGAGEEEV KKKKEEDGGR KEEVKKASEM EKEEKKEKEA
EKSDAKKSET EEKKAKQEEQ KKNDAEDKTT KKQEEKKNDA EDKLTRKQEE KKKNDAEDKT
VKKREEKKND AEDKTARKQE QKNLEGTKET EGMRLTREQR KKRDGESQEK KKERTRSRRL
EESKQQKKNK EEKKSGADRA LAAAESLRIE SAAKDAEKEG PERESPTGTD QGQQKKNSSS
TLTDSTLHRI NGDLRISLKT DKPDIRKCLS ALDQLSMLYV TSEHVQRHSE LIATLRKMRY
YRANQAIMDK ASMLYNRFKN AFLAGDGEEV VSAAFLRSLL QEKEETQLVR EKEEASEGEE
EKLEAKASVD SS
//
