ID A0A087X949_POEFO Unreviewed; 2326 AA.
AC A0A087X949;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Protein transport protein sec16 {ECO:0000256|RuleBase:RU364101};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000002302.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000002302.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the organization of the endoplasmic reticulum
CC exit sites (ERES), also known as transitional endoplasmic reticulum
CC (tER). Required for secretory cargo traffic from the endoplasmic
CC reticulum to the Golgi apparatus. {ECO:0000256|RuleBase:RU364101}.
CC -!- SUBUNIT: SEC16A and SEC16B are each present in multiple copies in a
CC heteromeric complex. {ECO:0000256|RuleBase:RU364101}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU364101}.
CC -!- SIMILARITY: Belongs to the SEC16 family.
CC {ECO:0000256|ARBA:ARBA00005927, ECO:0000256|RuleBase:RU364101}.
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DR EMBL; AYCK01014199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000002302; -.
DR Ensembl; ENSPFOT00000002306.1; ENSPFOP00000002302.1; ENSPFOG00000002239.1.
DR eggNOG; KOG1913; Eukaryota.
DR GeneTree; ENSGT00940000159324; -.
DR OMA; YKSPYDL; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:UniProt.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:InterPro.
DR GO; GO:0048208; P:COPII vesicle coating; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd09233; ACE1-Sec16-like; 1.
DR Gene3D; 1.25.40.1030; -; 1.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR024880; Sec16.
DR InterPro; IPR024340; Sec16_CCD.
DR PANTHER; PTHR13402:SF13; PROTEIN TRANSPORT PROTEIN SEC16A; 1.
DR PANTHER; PTHR13402; RGPR-RELATED; 1.
DR Pfam; PF12932; Sec16; 1.
DR Pfam; PF12931; Sec16_C; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU364101};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|RuleBase:RU364101};
KW Golgi apparatus {ECO:0000256|RuleBase:RU364101};
KW Membrane {ECO:0000256|RuleBase:RU364101};
KW Protein transport {ECO:0000256|RuleBase:RU364101};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transport {ECO:0000256|RuleBase:RU364101}.
FT DOMAIN 1392..1490
FT /note="Sec16 central conserved"
FT /evidence="ECO:0000259|Pfam:PF12932"
FT DOMAIN 1562..1798
FT /note="Ancestral coatomer element 1 Sec16/Sec31"
FT /evidence="ECO:0000259|Pfam:PF12931"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1959..2147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2169..2326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1066
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..1991
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2019..2043
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2083..2114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2115..2139
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2203..2315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2326 AA; 251346 MW; 05A84E823953D242 CRC64;
MQPTPRAGPP RAGPPRASMP NMTGRIRPQK HATAVTATML PPTQPITDPF AFGRAQPPMA
AGGLPTIPNS SPPQMQTPPN AMYSQLGSGL PPQPQLLENV PAAVAGPLAQ PLSGVTLFTP
QGTPSAGVFP SPSPTGYASA NSEQDYFNSR DPTASMSTDS SHMSPAPSNT LFNQDFQAQH
LGHPLPFQPL PLSSSSTQWA PDHSSRPPSV QNYFQPTVDP PARPSNIPPQ TQMYPSHSQS
PHHNAPTPPA YSGHPQIHPP APLQNPVAAA SSLLPDPNGP QHLNSHFQTQ SYFSQSSAPH
DLWFNQPVQD SGYHQMGTSS SHPQPPTESA GSPHVSSTGH GPVSQPVPSS VPATDAYGQE
SGTISMFFKG SDVENEETLA DERNKTLNGV AASFQHNSNP PSHSSHSDLT VDYQGVSVPD
HSRLPYMNES SHPLQGHIQK LPDNDFDHVE NLECVPNQEV LPNESSSSAA AAIAACNPVD
QFETGPNLET PDSIPRPMRS ASVSSNYSNL SHGSGTGSRR HQGVEGTFIQ QESPRLADNL
NASSAAASAA AAAAGGYFEQ IDTSPSGDVV VQGTVEHMWH PTPSPPKPTG IFQASANSSF
EPVRSHSVGV RPAEVDRAKM VAEGGSDSTS GNLEQPPDNM ENIFGPGQAP SSAPGDGLSS
QTHSVVHPHS RPSSRAFGAN RPCESPATTL WAQSDPTSLG TNILLAPAAL TVLAPLREPS
ADVIQPPEDC PLDLQASQRA QTASQQHSEN LENPPKVSDA EPVDSQSGLG YASLLVSSSL
HQPVLIAPPV SNYSVIPPSI PTPSSTQTNH GEVVSPERPP AQGLGASISQ PSALPSKQNP
LFSSGSAAFC SSAPNQGPLN LTRDKTVGAT SEITTPPLSQ PVHPPLSRGQ SLGAESHSTV
NSQPVSLVTA SVSNHNQTLN YELLDFSMHQ SHSQSQAYGQ PLSLHESSQS SNGFYLQVTK
DAQQGTSVST STSQAPPGPP PAAPNTQQTQ SEPPKTSNSQ VALQGQRDVP AVPVSGAQPS
HGQYSTPAQG PAGGNAPPPP AAPGVCPPGT HGAVPPGDPQ AVPAVAPRPP SSAGSHQDYV
HPPPPGSGQM YSSYYGNYGE YPDSRGQYPP GQYPPPPGDP RMQQYYQDAN YRGRGDPWYG
RYDGQNPGYH DPNYQYREPQ SERPNSRASQ YSDRPSSRLV KQQGYSEDYQ RQNRSAYGEY
YADYPKRYDY REGYNYGQYD RRYRGYYDQS YWSYYNETYR NGYYNQPGKD VYDAQWIYYP
GYDRSFDDDN VRGRDAYGDD FDRHSVHSER SAHSVHSSTS HHSRQSSFSS RSQQSQVYRS
QPDLVSAVYD TTQSTLPVDY SYGQYPNQTD ATQNYSQYMY PSEYTTDSTW IAPEQPPPRP
ATPEKFTMPH RCARFGPGGH LIQVLPNLPS AGQPALVEIH NMETMLQDTT DQAELRGFPG
PLIKEETHKV DVIKFSQNKA MECSRDNNLL DRDSARLLWD FIVLLCRQNG TVVGTDIADL
LLKEHRSVWL PGKSPNEANL IDFNNEPLAR AEEEPGAGPL SLLSDTFMIV PENVGKETER
FRELLLFGRK KDALEAAMKG GLWGHALLLA SKMDNRTHAR VMTRFANSLP MNDPLQTMYQ
LMSGRMPASA TCCGEEKWGD WRPHLAMVLS NLTHNMDLDT RTITTMGDTL GKASKGLTDA
AHFCYLMAQV GLGVYTKKST KLVLIGSNHS LAFNQFATNE AIQRTEAYEY AQSLGSQPCS
LPNFQVFKLI YACRLAESGL SAQAFHYCEV IAKTVLMHAS YYSPVLISQI IQMSEKLRFF
DPQLKERPEQ ELFIEPEWLI RLKQLDGQIR TGVITYNRDR STPAQFDCIS ESSDLEPQSP
HEPYSLPLEV DGQAPDNQLM SSLMPGPQPL AVQLMPPAPS SILHEGAAPA QLPPSSDVPQ
FYPVPPSGPP GQIPMPGFPP QDPGGVAHPH FHPQHEQAYP GMPQHMPPSP GHMAPMEQPL
PPNPEMHPTH PISSSPPRSS FTPQMDLYDH MAIMPSGRSS RRASESSTHS GGRERSNSAV
KQASPPPPSI PEQPRKEEAR KANASFPCKQ SKGWSFWPFG KRKNEAHLPD DKNPSIVWDE
KKNRWVDLNE PEEESKPPPP PPTGFPKMPQ MPGPGGPTAP PGAGSTVNMF SRKAVCVFSG
TRSRYVDVLN PSGTAKPSGV APAPVDLFAP LAPMPMPANL FVPSSAPSDQ QPLEGSEGGN
QEQNSPSSGA APQTLFSSGS QPTLEGPPVP DGSQSGELSR SSSMSSLSRE VSQHLNQERQ
SHPNQGTAPA GGVTFYNPTQ FSQTSAPSGG GQRPSRLGQR QYPVYK
//
